Format

Send to:

Choose Destination

CPLX4 complexin 4 [ Homo sapiens (human) ]

Gene ID: 339302, updated on 1-Jun-2020

Summary

Official Symbol
CPLX4provided by HGNC
Official Full Name
complexin 4provided by HGNC
Primary source
HGNC:HGNC:24330
See related
Ensembl:ENSG00000166569 MIM:609586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPXIV; CPX-IV
Summary
This gene likely encodes a member of the complexin family. The encoded protein may be involved in synaptic vesicle exocytosis. [provided by RefSeq, Jan 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CPLX4 in Genome Data Viewer
Location:
18q21.32
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (59295402..59318649, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (56962634..56985881, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene gastrin releasing peptide Neighboring gene retina and anterior neural fold homeobox Neighboring gene lectin, mannose binding 1 Neighboring gene uncharacterized LOC107985156

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41190, MGC125769, MGC125783, MGC125784, DKFZp686A0185, DKFZp686O0683

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complexin-4
Names
CPX IV
complexin IV

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181654.4NP_857637.1  complexin-4

    See identical proteins and their annotated locations for NP_857637.1

    Status: REVIEWED

    Source sequence(s)
    AC067859, AK123184, BM661846
    Consensus CDS
    CCDS11973.1
    UniProtKB/Swiss-Prot
    Q7Z7G2
    Related
    ENSP00000299721.3, ENST00000299721.3
    Conserved Domains (1) summary
    pfam05835
    Location:1140
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    59295402..59318649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center