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MSL1 MSL complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 339287, updated on 9-Feb-2020

Summary

Official Symbol
MSL1provided by HGNC
Official Full Name
MSL complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:27905
See related
Ensembl:ENSG00000188895 MIM:614801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSL-1
Expression
Ubiquitous expression in testis (RPKM 22.1), brain (RPKM 17.6) and 25 other tissues See more
Orthologs

Genomic context

See MSL1 in Genome Data Viewer
Location:
17q21.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40121971..40136917)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38278235..38293047)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 24 Neighboring gene small nucleolar RNA, C/D box 124 Neighboring gene thyroid hormone receptor alpha Neighboring gene nuclear receptor subfamily 1 group D member 1 Neighboring gene CASC3 exon junction complex subunit Neighboring gene microRNA 6866 Neighboring gene Rap guanine nucleotide exchange factor like 1 Neighboring gene microRNA 6867

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141861, DKFZp686J17211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
histone H4-K16 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
MSL complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MSL complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
male-specific lethal 1 homolog
Names
MSL1-like 1
male specific lethal 1 homolog
male-specific lethal 1-like 1
male-specific lethal-1 homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012241.2NP_001012241.1  male-specific lethal 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001012241.1

    Status: VALIDATED

    Source sequence(s)
    AC068669, AK125654, BC122543, BX647188, R23466
    Consensus CDS
    CCDS45670.1
    UniProtKB/Swiss-Prot
    Q68DK7
    UniProtKB/TrEMBL
    B3KWR7
    Related
    ENSP00000462945.1, ENST00000579565.5
    Conserved Domains (1) summary
    pfam15275
    Location:212328
    PEHE; PEHE domain
  2. NM_001365919.1NP_001352848.1  male-specific lethal 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068669
    Related
    ENSP00000381543.3, ENST00000398532.9
    Conserved Domains (2) summary
    pfam15275
    Location:475591
    PEHE; PEHE domain
    cl25574
    Location:243429
    TOP2c; TopoisomeraseII
  3. NM_001365920.1NP_001352849.1  male-specific lethal 1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068669
    Related
    ENSP00000462731.1, ENST00000578648.5
    Conserved Domains (2) summary
    pfam15275
    Location:459575
    PEHE; PEHE domain
    cl25574
    Location:243485
    TOP2c; TopoisomeraseII
  4. NM_001365921.1NP_001352850.1  male-specific lethal 1 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC068669
    Related
    ENSP00000463949.1, ENST00000577454.5
    Conserved Domains (1) summary
    cl25574
    Location:243429
    TOP2c; TopoisomeraseII

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40121971..40136917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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