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ARL16 ADP ribosylation factor like GTPase 16 [ Homo sapiens (human) ]

Gene ID: 339231, updated on 22-Jun-2020

Summary

Official Symbol
ARL16provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 16provided by HGNC
Primary source
HGNC:HGNC:27902
See related
Ensembl:ENSG00000214087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). This protein has been shown to have an inhibitory role in the cellular antiviral response. This gene product interacts with the C-terminal domain of the DEXD/H-box helicase 58 (DDX58) gene product. This interaction was found to suppress the association between the DDX58 gene product and RNA, thereby negatively regulating the activity of the DDX58 gene product. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in kidney (RPKM 11.1), thyroid (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See ARL16 in Genome Data Viewer
Location:
17q25.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81681165..81683924, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79648224..79650954, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene oxidoreductase like domain containing 1 Neighboring gene coiled-coil domain containing 137 Neighboring gene Sharpr-MPRA regulatory region 13823 Neighboring gene hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene microRNA 6786 Neighboring gene mitochondrial ribosomal protein L12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051248.1 RefSeqGene

    Range
    5001..7760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040025.3NP_001035114.2  ADP-ribosylation factor-like protein 16 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC139530
    Consensus CDS
    CCDS45813.1
    Related
    ENSP00000380635.4, ENST00000397498.8
  2. NM_001329608.1NP_001316537.1  ADP-ribosylation factor-like protein 16 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, including use of an alternate splice site compared to variant 1. This variant represents translation initiation at an alternate start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the alternate start codon to encode an isoform (2) that has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI149177, BC105078, BE746724, BX399419
    UniProtKB/Swiss-Prot
    Q0P5N6
    Related
    ENST00000571082.5
  3. NM_001329609.1NP_001316538.1  ADP-ribosylation factor-like protein 16 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC139530, AI149177, BE746724, CN359525
    Consensus CDS
    CCDS86652.1
    UniProtKB/TrEMBL
    I3L4Z7
    Related
    ENSP00000461674.1, ENST00000576135.5
    Conserved Domains (1) summary
    cl21455
    Location:3104
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_138058.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI149177, BC105078, BE746724, BG427716
  2. NR_138059.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon and lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC139530, AI149177, BE746724, BF684514
    Related
    ENST00000573392.5
  3. NR_138060.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' exon and has multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC139530, AI149177, BE746724, BG474883, DA088170

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81681165..81683924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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