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TMEM95 transmembrane protein 95 [ Homo sapiens (human) ]

Gene ID: 339168, updated on 23-Nov-2021

Summary

Official Symbol
TMEM95provided by HGNC
Official Full Name
transmembrane protein 95provided by HGNC
Primary source
HGNC:HGNC:27898
See related
Ensembl:ENSG00000182896 MIM:617814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ9390
Expression
Biased expression in testis (RPKM 4.1), thyroid (RPKM 3.1) and 1 other tissue See more
Orthologs
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Genomic context

See TMEM95 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7354968..7357219)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7258475..7260538)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene Sharpr-MPRA regulatory region 1992 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene tyrosine kinase non receptor 1 Neighboring gene phospholipid scramblase 3 Neighboring gene transmembrane protein 256

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in acrosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in acrosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sperm plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sperm-egg fusion protein TMEM95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320435.2NP_001307364.1  sperm-egg fusion protein TMEM95 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AY358218, BC040900
    Consensus CDS
    CCDS82052.1
    UniProtKB/Swiss-Prot
    Q3KNT9
    Related
    ENSP00000374632.4, ENST00000389982.8
    Conserved Domains (1) summary
    pfam15203
    Location:17138
    TMEM95; TMEM95 family
  2. NM_001320436.2NP_001307365.1  sperm-egg fusion protein TMEM95 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC026954, BC107110
    Consensus CDS
    CCDS82051.1
    UniProtKB/Swiss-Prot
    Q3KNT9
    Related
    ENSP00000460828.1, ENST00000576060.6
    Conserved Domains (1) summary
    pfam15203
    Location:17154
    TMEM95; TMEM95 family
  3. NM_198154.3NP_937797.1  sperm-egg fusion protein TMEM95 isoform 2 precursor

    See identical proteins and their annotated locations for NP_937797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC026954
    Consensus CDS
    CCDS32546.1
    UniProtKB/Swiss-Prot
    Q3KNT9
    Related
    ENSP00000331466.4, ENST00000330767.4
    Conserved Domains (1) summary
    pfam15203
    Location:17162
    TMEM95; TMEM95 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7354968..7357219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024571.1XP_016880060.1  sperm-egg fusion protein TMEM95 isoform X6

  2. XM_017024568.1XP_016880057.1  sperm-egg fusion protein TMEM95 isoform X4

    UniProtKB/Swiss-Prot
    Q3KNT9
    Conserved Domains (1) summary
    pfam15203
    Location:17154
    TMEM95; TMEM95 family
  3. XM_017024565.1XP_016880054.1  sperm-egg fusion protein TMEM95 isoform X1

  4. XM_017024566.1XP_016880055.1  sperm-egg fusion protein TMEM95 isoform X2

  5. XM_017024567.1XP_016880056.1  sperm-egg fusion protein TMEM95 isoform X3

  6. XM_017024569.1XP_016880058.1  sperm-egg fusion protein TMEM95 isoform X4

    UniProtKB/Swiss-Prot
    Q3KNT9
    Conserved Domains (1) summary
    pfam15203
    Location:17154
    TMEM95; TMEM95 family
  7. XM_017024570.1XP_016880059.1  sperm-egg fusion protein TMEM95 isoform X5

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p13 PATCHES

    Range
    113521..115584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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