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JMJD8 jumonji domain containing 8 [ Homo sapiens (human) ]

Gene ID: 339123, updated on 1-Jun-2020

Summary

Official Symbol
JMJD8provided by HGNC
Official Full Name
jumonji domain containing 8provided by HGNC
Primary source
HGNC:HGNC:14148
See related
Ensembl:ENSG00000161999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP14397; C16orf20
Expression
Ubiquitous expression in thyroid (RPKM 36.7), kidney (RPKM 34.2) and 25 other tissues See more
Orthologs

Genomic context

See JMJD8 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (681670..684334, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (731667..734440, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene rhomboid like 1 Neighboring gene long intergenic non-protein coding RNA 2867 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene WD repeat domain 24 Neighboring gene F-box and leucine rich repeat protein 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pyruvate kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
jmjC domain-containing protein 8
Names
jumonji domain-containing protein 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005920.4NP_001005920.3  jmjC domain-containing protein 8 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    Z92544
    Consensus CDS
    CCDS45369.1
    Related
    ENSP00000477481.1, ENST00000609261.6
    Conserved Domains (1) summary
    cl21464
    Location:54248
    cupin_like; Conserved domain found in cupin and related proteins
  2. NM_001323918.3NP_001310847.2  jmjC domain-containing protein 8 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AI370749, BC137100, BX335015, HY073770, Z92544
    Conserved Domains (1) summary
    cl21464
    Location:54240
    cupin_like; Conserved domain found in cupin and related proteins
  3. NM_001323919.3NP_001310848.2  jmjC domain-containing protein 8 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AI370749, BC137100, BG481039, Z92544
    Related
    ENSP00000458106.1, ENST00000562111.1
  4. NM_001323920.3NP_001310849.2  jmjC domain-containing protein 8 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AI370749, BI767435, Z92544
    Related
    ENSP00000454358.1, ENST00000562824.5
    Conserved Domains (1) summary
    cl21464
    Location:34218
    cupin_like; Conserved domain found in cupin and related proteins
  5. NM_001323922.3NP_001310851.2  jmjC domain-containing protein 8 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AI370749, BC137101, BG423721, CN371155, HY023676, HY073770, Z92544
    Conserved Domains (1) summary
    cl21464
    Location:34210
    cupin_like; Conserved domain found in cupin and related proteins

RNA

  1. NR_136650.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF370420, AI370749, AL524336, HY073770, Z92544
    Related
    ENST00000568689.5
  2. NR_136651.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI370749, AL524922, CD674105, Z92544
  3. NR_136652.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI370749, BC137100, BG284477, BG826580, HY073770, Z92544

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    681670..684334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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