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PRSS53 serine protease 53 [ Homo sapiens (human) ]

Gene ID: 339105, updated on 14-Jul-2021

Summary

Official Symbol
PRSS53provided by HGNC
Official Full Name
serine protease 53provided by HGNC
Primary source
HGNC:HGNC:34407
See related
Ensembl:ENSG00000151006 MIM:610561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POL3S; UNQ308
Expression
Ubiquitous expression in skin (RPKM 1.8), spleen (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

See PRSS53 in Genome Data Viewer
Location:
16p11.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (31083424..31089652, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31094745..31100130, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928762 Neighboring gene zinc finger protein 668 Neighboring gene zinc finger protein 646 Neighboring gene vitamin K epoxide reductase complex subunit 1 Neighboring gene branched chain keto acid dehydrogenase kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies three psoriasis susceptibility loci.
GeneReviews: Not available
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease 53
Names
EDTP308
polyserase-3
polyserine protease 3
protease, serine 53
NP_001034592.1
XP_011544118.1
XP_011544119.1
XP_011544120.1
XP_011544121.1
XP_011544122.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039503.3NP_001034592.1  serine protease 53 precursor

    See identical proteins and their annotated locations for NP_001034592.1

    Status: VALIDATED

    Source sequence(s)
    AC135050
    Consensus CDS
    CCDS42153.1
    UniProtKB/Swiss-Prot
    Q2L4Q9
    Related
    ENSP00000280606.6, ENST00000280606.6
    Conserved Domains (2) summary
    smart00020
    Location:43267
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42269
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    31083424..31089652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545819.2XP_011544121.1  serine protease 53 isoform X4

    Conserved Domains (3) summary
    smart00020
    Location:43267
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42269
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:312465
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_011545820.2XP_011544122.1  serine protease 53 isoform X5

    Conserved Domains (2) summary
    smart00020
    Location:43267
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42269
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_011545816.2XP_011544118.1  serine protease 53 isoform X1

    Conserved Domains (3) summary
    smart00020
    Location:43314
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42316
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:359512
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. XM_011545817.2XP_011544119.1  serine protease 53 isoform X2

    Conserved Domains (2) summary
    smart00020
    Location:43314
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42316
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_011545818.3XP_011544120.1  serine protease 53 isoform X3

    Conserved Domains (2) summary
    smart00020
    Location:43314
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42316
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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