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mmy mummy [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33903, updated on 6-Jul-2026
Official Symbol
mmyprovided by FlyBase
Official Full Name
mummyprovided by FlyBase
Primary source
FLYBASE:FBgn0259749
Locus tag
Dmel_CG9535
See related
AllianceGenome:FB:FBgn0259749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.242; BcDNA:LD24639; cao; CG9535; cys; cyst; cystic; Dmel\CG9535; l(2)k13717b; LD44264; mum; UAP1
Summary
Enables UDP-N-acetylglucosamine diphosphorylase activity. Involved in several processes, including amino sugar biosynthetic process; morphogenesis of embryonic epithelium; and nervous system development. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut; hindgut proper primordium; larval tracheal system; and primary tracheal branch. Orthologous to several human genes including UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See mmy in Genome Data Viewer
Location:
26D7-26D7; 2-20 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6468538..6473904, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6468538..6473904, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ring finger and CHY zinc finger domain containing 1 Neighboring gene HemK methyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene Sec61 alpha subunit

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons. Manavalan MA, et al. Sci Signal, 2017 Jun 20. PMID 28634210, Free PMC Article
  2. Effects of benzoylphenylurea on chitin synthesis and orientation in the cuticle of the Drosophila larva. Gangishetti U, et al. Eur J Cell Biol, 2009 Mar. PMID 18996617
  3. O-GlcNAcylation Dampens Dpp/BMP Signaling to Ensure Proper Drosophila Embryonic Development. Moulton MJ, et al. Dev Cell, 2020 May 4. PMID 32369743
  4. Mummy encodes an UDP-N-acetylglucosamine-dipohosphorylase and is required during Drosophila dorsal closure and nervous system development. Schimmelpfeng K, et al. Mech Dev, 2006 Jun. PMID 16793242
  5. Tubulogenesis: an inside job. Swanson LE, et al. Curr Biol, 2006 Jan 24. PMID 16431358, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mmy is required for Slit secretion and for maintaining Robo abundance and distribution in the developing nervous system in Drosophila.
    Title: The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons.
  2. mmy is essential for multiple developmental events in Drosophila.
    Title: Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine diphosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine diphosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-N-acetylglucosamine diphosphorylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
enables uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-N-acetylglucosamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based embryonic cuticle biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic epithelial tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
mummy
Names
CG9535-PA
CG9535-PB
CG9535-PD
UDP-GlcNAc pyrophosphorylase
UDP-N-acetylglucosamine diphosphorylase
UDP-N-acetylglucosamine pyrophosphorylase
cabrio
cystic
mmy-PA
mmy-PB
mmy-PD
NP_001285673.1
NP_609032.1
NP_723183.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6468538..6473904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298744.1 → NP_001285673.1  mummy, isoform D

    See identical proteins and their annotated locations for NP_001285673.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGT8, Q8IPJ6
    Conserved Domains (2) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    cl21455
    Location:1 → 86
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_164690.2 → NP_723183.1  mummy, isoform B

    See identical proteins and their annotated locations for NP_723183.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGT8, Q8IPJ6
    Related
    FBpp0078899
    Conserved Domains (2) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    cl21455
    Location:1 → 86
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_135188.3 → NP_609032.1  mummy, isoform A

    See identical proteins and their annotated locations for NP_609032.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMI1, Q8IGT8, Q9Y0Z0
    Related
    FBpp0078898
    Conserved Domains (2) summary
    cd04193
    Location:125 → 447
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    cl21455
    Location:34 → 123
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGT8 Q8IGT8
Q8IPJ6 Q8IPJ6
Q9Y0Z0 Q9Y0Z0

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