Format

Send to:

Choose Destination

TAFA2 TAFA chemokine like family member 2 [ Homo sapiens (human) ]

Gene ID: 338811, updated on 14-Apr-2019

Summary

Official Symbol
TAFA2provided by HGNC
Official Full Name
TAFA chemokine like family member 2provided by HGNC
Primary source
HGNC:HGNC:21589
See related
Ensembl:ENSG00000198673 MIM:617496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAFA-2; FAM19A2
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.8), placenta (RPKM 1.2) and 5 other tissues See more
Orthologs

Genomic context

See TAFA2 in Genome Data Viewer
Location:
12q14.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (61708248..62260104, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (62102029..62586620, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene double homeobox 4 like 52 (pseudogene) Neighboring gene uncharacterized LOC105369793 Neighboring gene ribosomal protein L21 pseudogene 104 Neighboring gene keratin 8 pseudogene 19 Neighboring gene ribosomal protein S3 pseudogene 6 Neighboring gene Kruppel like factor 17 pseudogene 1 Neighboring gene microRNA 6125 Neighboring gene ubiquitin specific peptidase 15 Neighboring gene RNA, U6 small nuclear 595, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
NHGRI GWA Catalog
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
NHGRI GWA Catalog
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC42403, DKFZp761E1217, DKFZp781P0552

Gene Ontology Provided by GOA

Process Evidence Code Pubs
memory ISS
Inferred from Sequence or Structural Similarity
more info
 
visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
chemokine-like protein TAFA-2; protein FAM19A2
Names
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
family with sequence similarity 19 member A2, C-C motif chemokine like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178539.4NP_848634.1  chemokine-like protein TAFA-2 precursor

    See identical proteins and their annotated locations for NP_848634.1

    Status: REVIEWED

    Source sequence(s)
    AL834160, BX110188, DA242708, DA721025, DB535669
    Consensus CDS
    CCDS8962.1
    UniProtKB/Swiss-Prot
    Q8N3H0
    Related
    ENSP00000393987.3, ENST00000416284.7
    Conserved Domains (1) summary
    pfam12020
    Location:42128
    TAFA; TAFA family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    61708248..62260104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448963.1XP_024304731.1  protein FAM19A2 isoform X2

    Related
    ENSP00000449516.1, ENST00000552075.5
    Conserved Domains (1) summary
    pfam12020
    Location:43129
    TAFA; TAFA family
  2. XM_024448962.1XP_024304730.1  protein FAM19A2 isoform X1

    Conserved Domains (1) summary
    pfam12020
    Location:91177
    TAFA; TAFA family
  3. XM_011538272.2XP_011536574.1  protein FAM19A2 isoform X3

    See identical proteins and their annotated locations for XP_011536574.1

    UniProtKB/Swiss-Prot
    Q8N3H0
    Related
    ENSP00000447305.1, ENST00000551619.5
    Conserved Domains (1) summary
    pfam12020
    Location:42128
    TAFA; TAFA family
  4. XM_024448965.1XP_024304733.1  protein FAM19A2 isoform X3

    Conserved Domains (1) summary
    pfam12020
    Location:42128
    TAFA; TAFA family
  5. XM_024448964.1XP_024304732.1  protein FAM19A2 isoform X3

    Conserved Domains (1) summary
    pfam12020
    Location:42128
    TAFA; TAFA family
  6. XM_024448966.1XP_024304734.1  protein FAM19A2 isoform X3

    Conserved Domains (1) summary
    pfam12020
    Location:42128
    TAFA; TAFA family
Support Center