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KRT79 keratin 79 [ Homo sapiens (human) ]

Gene ID: 338785, updated on 1-Jun-2020

Summary

Official Symbol
KRT79provided by HGNC
Official Full Name
keratin 79provided by HGNC
Primary source
HGNC:HGNC:28930
See related
Ensembl:ENSG00000185640 MIM:611160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K6L; KRT6L
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Expression
Biased expression in skin (RPKM 6.3), fat (RPKM 0.8) and 1 other tissue See more
Orthologs

Genomic context

See KRT79 in Genome Data Viewer
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52821408..52834311, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53215231..53228077, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 3 Neighboring gene keratin 4 Neighboring gene keratin 78 Neighboring gene ribosomal protein L7 pseudogene 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ26646

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type II cytoskeletal 79
Names
CK-79
K79
cytokeratin-79
keratin 6L
keratin 79, type II
type-II keratin Kb38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012323.1 RefSeqGene

    Range
    4983..17886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175834.3NP_787028.1  keratin, type II cytoskeletal 79

    See identical proteins and their annotated locations for NP_787028.1

    Status: REVIEWED

    Source sequence(s)
    AC107016, AJ564105, BC039148
    Consensus CDS
    CCDS8839.1
    UniProtKB/Swiss-Prot
    Q5XKE5
    Related
    ENSP00000328358.5, ENST00000330553.6
    Conserved Domains (2) summary
    pfam00038
    Location:141456
    Filament; Intermediate filament protein
    pfam16208
    Location:30138
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52821408..52834311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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