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TMEM119 transmembrane protein 119 [ Homo sapiens (human) ]

Gene ID: 338773, updated on 13-Mar-2020

Summary

Official Symbol
TMEM119provided by HGNC
Official Full Name
transmembrane protein 119provided by HGNC
Primary source
HGNC:HGNC:27884
See related
Ensembl:ENSG00000183160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBIF
Expression
Broad expression in gall bladder (RPKM 16.3), lymph node (RPKM 16.2) and 21 other tissues See more
Orthologs

Genomic context

See TMEM119 in Genome Data Viewer
Location:
12q23.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (108589846..108598099, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108983622..108991894, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene spliceosome associated factor 3, U4/U6 recycling protein Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene uncharacterized LOC105369968 Neighboring gene selectin P ligand Neighboring gene microRNA 4496

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
endochondral ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of osteoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatid differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 119
Names
osteoblast induction factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181724.3NP_859075.2  transmembrane protein 119 precursor

    See identical proteins and their annotated locations for NP_859075.2

    Status: VALIDATED

    Source sequence(s)
    AL521683, BC096825, DC349145, ES311302
    Consensus CDS
    CCDS9119.1
    UniProtKB/Swiss-Prot
    Q4V9L6
    Related
    ENSP00000376553.3, ENST00000392806.4
    Conserved Domains (1) summary
    pfam15724
    Location:26277
    TMEM119; TMEM119 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    108589846..108598099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538271.2XP_011536573.1  transmembrane protein 119 isoform X1

    See identical proteins and their annotated locations for XP_011536573.1

    UniProtKB/Swiss-Prot
    Q4V9L6
    Conserved Domains (1) summary
    pfam15724
    Location:26277
    TMEM119; TMEM119 family
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