U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM119 transmembrane protein 119 [ Homo sapiens (human) ]

Gene ID: 338773, updated on 22-Sep-2022

Summary

Official Symbol
TMEM119provided by HGNC
Official Full Name
transmembrane protein 119provided by HGNC
Primary source
HGNC:HGNC:27884
See related
Ensembl:ENSG00000183160 MIM:618989; AllianceGenome:HGNC:27884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBIF
Summary
Involved in positive regulation of bone mineralization; positive regulation of osteoblast differentiation; and positive regulation of osteoblast proliferation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in gall bladder (RPKM 16.3), lymph node (RPKM 16.2) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMEM119 in Genome Data Viewer
Location:
12q23.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108589851..108598084, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108564436..108572683, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108983627..108991860, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene spliceosome associated factor 3, U4/U6 recycling protein Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene uncharacterized LOC105369968 Neighboring gene selectin P ligand Neighboring gene microRNA 4496

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in endochondral ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of osteoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatid differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 119
Names
osteoblast induction factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181724.3NP_859075.2  transmembrane protein 119 precursor

    See identical proteins and their annotated locations for NP_859075.2

    Status: VALIDATED

    Source sequence(s)
    AL521683, BC096825, DC349145, ES311302
    Consensus CDS
    CCDS9119.1
    UniProtKB/Swiss-Prot
    Q4V9L6, Q8N2F5
    Related
    ENSP00000376553.3, ENST00000392806.4
    Conserved Domains (1) summary
    pfam15724
    Location:26277
    TMEM119; TMEM119 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    108589851..108598084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538271.3XP_011536573.1  transmembrane protein 119 isoform X1

    See identical proteins and their annotated locations for XP_011536573.1

    UniProtKB/Swiss-Prot
    Q4V9L6, Q8N2F5
    Conserved Domains (1) summary
    pfam15724
    Location:26277
    TMEM119; TMEM119 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    108564436..108572683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)