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C1QL4 complement C1q like 4 [ Homo sapiens (human) ]

Gene ID: 338761, updated on 12-Aug-2022

Summary

Official Symbol
C1QL4provided by HGNC
Official Full Name
complement C1q like 4provided by HGNC
Primary source
HGNC:HGNC:31416
See related
Ensembl:ENSG00000186897 MIM:615229; AllianceGenome:HGNC:31416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRP11; C1QTNF11
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See C1QL4 in Genome Data Viewer
Location:
12q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49332409..49337188, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (49294599..49299378, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49726192..49730971, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TROAP and PRPH antisense RNA 1 Neighboring gene peripherin Neighboring gene trophinin associated protein Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene spermatogenesis associated serine rich 2 Neighboring gene FGFR1 oncogene partner 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC131708

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complement C1q-like protein 4
Names
C1q and tumor necrosis factor-related protein 11
C1q/TNF-related protein 11
complement component 1, q subcomponent like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008223.2NP_001008224.1  complement C1q-like protein 4 precursor

    See identical proteins and their annotated locations for NP_001008224.1

    Status: VALIDATED

    Source sequence(s)
    AC125611, AF466366
    Consensus CDS
    CCDS31793.1
    UniProtKB/Swiss-Prot
    Q86Z23
    UniProtKB/TrEMBL
    A0A3B0INP7
    Related
    ENSP00000335285.3, ENST00000334221.5
    Conserved Domains (1) summary
    pfam00386
    Location:111235
    C1q; C1q domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    49332409..49337188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538270.3XP_011536572.1  complement C1q-like protein 4 isoform X1

    Conserved Domains (1) summary
    pfam00386
    Location:111216
    C1q; C1q domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    49294599..49299378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)