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ANKRD42 ankyrin repeat domain 42 [ Homo sapiens (human) ]

Gene ID: 338699, updated on 7-Oct-2019

Summary

Official Symbol
ANKRD42provided by HGNC
Official Full Name
ankyrin repeat domain 42provided by HGNC
Primary source
HGNC:HGNC:26752
See related
Ensembl:ENSG00000137494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SARP; PPP1R79
Expression
Broad expression in testis (RPKM 10.9), thyroid (RPKM 3.7) and 24 other tissues See more
Orthologs

Genomic context

See ANKRD42 in Genome Data Viewer
Location:
11q14.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (83193712..83256099)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82904754..82967719)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BCAS2 pseudogene 1 Neighboring gene PCF11 cleavage and polyadenylation factor subunit Neighboring gene uncharacterized LOC100506282 Neighboring gene PCF11 antisense RNA 1 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 4 Neighboring gene ribosomal protein L32 pseudogene 24 Neighboring gene coiled-coil domain containing 90B Neighboring gene uncharacterized LOC105369420

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37874

General protein information

Preferred Names
ankyrin repeat domain-containing protein 42
Names
protein phosphatase 1, regulatory subunit 79
several ankyrin repeat protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300972.2NP_001287901.1  ankyrin repeat domain-containing protein 42 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP000873, BC045621, BU674837, DQ508815
    Consensus CDS
    CCDS76458.1
    UniProtKB/Swiss-Prot
    Q8N9B4
    UniProtKB/TrEMBL
    A1XPJ0, E9PP91
    Related
    ENSP00000434666.1, ENST00000531895.5
    Conserved Domains (3) summary
    cd00204
    Location:59179
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5990
    ANK; ANK repeat [structural motif]
    cl25732
    Location:332482
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001300973.2NP_001287902.1  ankyrin repeat domain-containing protein 42 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) lacks an alternate internal aa and has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AP000873, BC045621, BU674837, EF041819
    Consensus CDS
    CCDS76457.1
    UniProtKB/Swiss-Prot
    Q8N9B4
    UniProtKB/TrEMBL
    A1DRY3, F8W6I9
    Related
    ENSP00000260047.6, ENST00000260047.10
    Conserved Domains (3) summary
    cd00204
    Location:59178
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5990
    ANK; ANK repeat [structural motif]
    cl25732
    Location:331481
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001300975.2NP_001287904.1  ankyrin repeat domain-containing protein 42 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AP000873, BC045621, BC171752
    Consensus CDS
    CCDS76459.1
    UniProtKB/Swiss-Prot
    Q8N9B4
    UniProtKB/TrEMBL
    E9PIL2
    Related
    ENSP00000435790.1, ENST00000533342.6
    Conserved Domains (7) summary
    COG0666
    Location:94375
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:59179
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08663
    Location:430472
    HalX; HalX domain
    pfam12796
    Location:64156
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2680
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:5990
    ANK; ANK repeat [structural motif]
    cl09111
    Location:394482
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  4. NM_001300976.2NP_001287905.1  ankyrin repeat domain-containing protein 42 isoform 5

    See identical proteins and their annotated locations for NP_001287905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP000873, BC045621, BX648690
    Consensus CDS
    CCDS73356.1
    UniProtKB/Swiss-Prot
    Q8N9B4
    UniProtKB/TrEMBL
    E9PKE2
    Related
    ENSP00000433585.1, ENST00000526731.5
    Conserved Domains (3) summary
    cd00204
    Location:59179
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5990
    ANK; ANK repeat [structural motif]
    cl00748
    Location:210230
    Ribosomal_L32_L32e; Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the ...
  5. NM_001300977.2NP_001287906.1  ankyrin repeat domain-containing protein 42 isoform 6

    See identical proteins and their annotated locations for NP_001287906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP000873, BC045621, BX648690
    Consensus CDS
    CCDS73355.1
    UniProtKB/Swiss-Prot
    Q8N9B4
    Related
    ENSP00000377049.3, ENST00000393389.7
    Conserved Domains (2) summary
    cd00204
    Location:59179
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5990
    ANK; ANK repeat [structural motif]
  6. NM_182603.4NP_872409.2  ankyrin repeat domain-containing protein 42 isoform 4

    See identical proteins and their annotated locations for NP_872409.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 5' end and lacks an alternate exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AK095193, AP000873, BC045621
    Consensus CDS
    CCDS8265.1
    UniProtKB/Swiss-Prot
    Q8N9B4
    Related
    ENSP00000377051.2, ENST00000393392.6
    Conserved Domains (3) summary
    cd00204
    Location:65184
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:6495
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:3085
    Ank_4; Ankyrin repeats (many copies)

RNA

  1. NR_125355.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK310765, AP000873, BC045621, BX648690

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    83193712..83256099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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