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TMEM225 transmembrane protein 225 [ Homo sapiens (human) ]

Gene ID: 338661, updated on 22-Sep-2022

Summary

Official Symbol
TMEM225provided by HGNC
Official Full Name
transmembrane protein 225provided by HGNC
Primary source
HGNC:HGNC:32390
See related
Ensembl:ENSG00000204300 AllianceGenome:HGNC:32390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMP22CD; SPATA47; PPP1R154
Summary
Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in acrosomal membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 3.9) See more
Orthologs
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Genomic context

See TMEM225 in Genome Data Viewer
Location:
11q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (123882920..123885670, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (123911680..123914430, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (123753627..123756377, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily M member 2 pseudogene Neighboring gene olfactory receptor family 6 subfamily M member 3 pseudogene Neighboring gene olfactory receptor family 8 subfamily D member 4 Neighboring gene olfactory receptor family 4 subfamily D member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 225
Names
PMP22 claudin domain-containing protein
protein phosphatase 1, regulatory subunit 154
spermatogenesis associated 47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013743.3NP_001013765.2  transmembrane protein 225 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA437068, AP002407, AY634366, BX091037
    Consensus CDS
    CCDS31697.1
    UniProtKB/Swiss-Prot
    Q6GV28
    Related
    ENSP00000364166.2, ENST00000375026.7
  2. NM_001363605.2NP_001350534.1  transmembrane protein 225 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP002407, KF455554
    Related
    ENSP00000431282.1, ENST00000528595.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    123882920..123885670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542802.4XP_011541104.1  transmembrane protein 225 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    123911680..123914430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)