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DUSP29 dual specificity phosphatase 29 [ Homo sapiens (human) ]

Gene ID: 338599, updated on 26-Oct-2022

Summary

Official Symbol
DUSP29provided by HGNC
Official Full Name
dual specificity phosphatase 29provided by HGNC
Primary source
HGNC:HGNC:23481
See related
Ensembl:ENSG00000188716 MIM:618574; AllianceGenome:HGNC:23481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUPD1; FMDSP; DUSP27
Summary
Enables protein homodimerization activity and protein tyrosine/serine/threonine phosphatase activity. Involved in protein dephosphorylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See DUSP29 in Genome Data Viewer
Location:
10q22.2
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75037472..75073642, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (75911002..75947146, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76797230..76833400, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902459 Neighboring gene VISTA enhancer hs1500 Neighboring gene lysine acetyltransferase 6B Neighboring gene small nucleolar RNA, C/D box 172 Neighboring gene peptidylprolyl isomerase A pseudogene 13 Neighboring gene dual specificity phosphatase 13 Neighboring gene sterile alpha motif domain containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide and gene-based association studies of anxiety disorders in European and african american samples.
EBI GWAS Catalog
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity phosphatase 29
Names
atypical dual-specific protein phosphatase
dual specificity phosphatase 27
dual specificity phosphatase DUPD1
dual specificity phosphatase and pro isomerase domain containing 1
NP_001003892.1
NP_001371838.1
XP_016871665.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003892.3NP_001003892.1  dual specificity phosphatase 29

    See identical proteins and their annotated locations for NP_001003892.1

    Status: VALIDATED

    Source sequence(s)
    AC018511, AL392111
    Consensus CDS
    CCDS31223.1
    UniProtKB/Swiss-Prot
    B2RP93, Q68J44
    Related
    ENSP00000340609.5, ENST00000338487.6
    Conserved Domains (1) summary
    cd14575
    Location:45201
    DUPD1; dual specificity phosphatase and pro isomerase domain containing 1
  2. NM_001384909.1NP_001371838.1  dual specificity phosphatase 29

    Status: VALIDATED

    Source sequence(s)
    AC018511, AL392111
    Consensus CDS
    CCDS31223.1
    UniProtKB/Swiss-Prot
    B2RP93
    Conserved Domains (1) summary
    cd14575
    Location:45201
    DUPD1; dual specificity phosphatase and pro isomerase domain containing 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    75037472..75073642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016176.2XP_016871665.1  dual specificity phosphatase 29 isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646202.1 Reference GRCh38.p14 PATCHES

    Range
    242148..263241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    75911002..75947146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)