Format

Send to:

Choose Destination

DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 338599, updated on 5-Aug-2018

Summary

Official Symbol
DUPD1provided by HGNC
Official Full Name
dual specificity phosphatase and pro isomerase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:23481
See related
Ensembl:ENSG00000188716 Vega:OTTHUMG00000018512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMDSP; DUSP27
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See DUPD1 in Genome Data Viewer
Location:
10q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (75026427..75073827, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76797230..76833383, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lysine acetyltransferase 6B Neighboring gene uncharacterized LOC101929165 Neighboring gene small nucleolar RNA, C/D box 172 Neighboring gene peptidylprolyl isomerase A pseudogene 13 Neighboring gene dual specificity phosphatase 13 Neighboring gene sterile alpha motif domain containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide and gene-based association studies of anxiety disorders in European and african american samples.
NHGRI GWA Catalog
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity phosphatase DUPD1
Names
atypical dual-specific protein phosphatase
dual specificity phosphatase 27
NP_001003892.1
XP_011538049.1
XP_016871665.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003892.2NP_001003892.1  dual specificity phosphatase DUPD1

    See identical proteins and their annotated locations for NP_001003892.1

    Status: VALIDATED

    Source sequence(s)
    BC137321
    Consensus CDS
    CCDS31223.1
    UniProtKB/Swiss-Prot
    Q68J44
    Related
    ENSP00000340609.5, OTTHUMP00000019871, ENST00000338487.5
    Conserved Domains (1) summary
    cd00127
    Location:54197
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    75026427..75073827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539747.2XP_011538049.1  dual specificity phosphatase DUPD1 isoform X1

    See identical proteins and their annotated locations for XP_011538049.1

    UniProtKB/Swiss-Prot
    Q68J44
    Conserved Domains (1) summary
    cd00127
    Location:54197
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. XM_017016176.1XP_016871665.1  dual specificity phosphatase DUPD1 isoform X2

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_009646202.1 Reference GRCh38.p12 PATCHES

    Range
    242460..263259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center