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ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 338596, updated on 22-Sep-2022

Summary

Official Symbol
ST8SIA6provided by HGNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:23317
See related
Ensembl:ENSG00000148488 MIM:610139; AllianceGenome:HGNC:23317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIA8F; SIAT8F; SIAT8-F; ST8SiaVI; ST8SIA-VI
Summary
This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Broad expression in lung (RPKM 3.3), heart (RPKM 1.0) and 14 other tissues See more
Orthologs
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Genomic context

See ST8SIA6 in Genome Data Viewer
Location:
10p12.33
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17315421..17454595, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17333849..17473031, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17357420..17496594, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene VIM antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 14556 Neighboring gene vimentin Neighboring gene ST8SIA6 antisense RNA 1 Neighboring gene uncharacterized LOC105376436 Neighboring gene uncharacterized LOC105376437 Neighboring gene Sharpr-MPRA regulatory region 15274

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity TAS
Traceable Author Statement
more info
 
enables sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in ganglioside biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in glycolipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in glycoprotein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oligosaccharide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-2,8-sialyltransferase 8F
Names
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6
sialyltransferase 8F (alpha-2, 8-sialyltransferase)
sialyltransferase St8Sia VI
NP_001004470.1
NP_001332890.1
XP_016871663.1
XP_024303745.1
XP_024303746.1
XP_047281110.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051597.1 RefSeqGene

    Range
    6372..145546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004470.3NP_001004470.1  alpha-2,8-sialyltransferase 8F isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL158164, AL160289, BC137103
    Consensus CDS
    CCDS31158.1
    UniProtKB/Swiss-Prot
    P61647, Q5VZH4
    Related
    ENSP00000366827.4, ENST00000377602.5
    Conserved Domains (1) summary
    pfam00777
    Location:138391
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001345961.2NP_001332890.1  alpha-2,8-sialyltransferase 8F isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL158164, AL160289
    Conserved Domains (1) summary
    pfam00777
    Location:15240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_144322.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL158164, AL160289, BC144472

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    17315421..17454595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016174.2XP_016871663.1  alpha-2,8-sialyltransferase 8F isoform X1

  2. XM_024447977.2XP_024303745.1  alpha-2,8-sialyltransferase 8F isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:15240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_024447978.2XP_024303746.1  alpha-2,8-sialyltransferase 8F isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:15240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_047425154.1XP_047281110.1  alpha-2,8-sialyltransferase 8F isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    17333849..17473031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)