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ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 338596, updated on 1-Jun-2020

Summary

Official Symbol
ST8SIA6provided by HGNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:23317
See related
Ensembl:ENSG00000148488 MIM:610139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIA8F; SIAT8F; SIAT8-F; ST8SiaVI; ST8SIA-VI
Summary
This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Broad expression in lung (RPKM 3.3), heart (RPKM 1.0) and 14 other tissues See more
Orthologs

Genomic context

See ST8SIA6 in Genome Data Viewer
Location:
10p12.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (17315414..17455966, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17361282..17496408, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tRNA aspartic acid methyltransferase 1 Neighboring gene VIM antisense RNA 1 Neighboring gene vimentin Neighboring gene ST8SIA6 antisense RNA 1 Neighboring gene uncharacterized LOC105376436 Neighboring gene uncharacterized LOC105376437 Neighboring gene PRP38 domain containing A pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
carbohydrate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ganglioside biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
glycolipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
glycoprotein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-2,8-sialyltransferase 8F
Names
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6
sialyltransferase 8F (alpha-2, 8-sialyltransferase)
sialyltransferase St8Sia VI
NP_001004470.1
NP_001332890.1
XP_016871663.1
XP_016871664.1
XP_024303742.1
XP_024303743.1
XP_024303744.1
XP_024303745.1
XP_024303746.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051597.1 RefSeqGene

    Range
    6372..145546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004470.3NP_001004470.1  alpha-2,8-sialyltransferase 8F isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL158164, AL160289, BC137103
    Consensus CDS
    CCDS31158.1
    UniProtKB/Swiss-Prot
    P61647
    Related
    ENSP00000366827.4, ENST00000377602.5
    Conserved Domains (1) summary
    pfam00777
    Location:138391
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001345961.2NP_001332890.1  alpha-2,8-sialyltransferase 8F isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL158164, AL160289
    Conserved Domains (1) summary
    pfam00777
    Location:13240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_144322.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL158164, AL160289, BC144472

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    17315414..17455966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016174.1XP_016871663.1  alpha-2,8-sialyltransferase 8F isoform X1

  2. XM_024447974.1XP_024303742.1  alpha-2,8-sialyltransferase 8F isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:13240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_024447975.1XP_024303743.1  alpha-2,8-sialyltransferase 8F isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:13240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_024447977.1XP_024303745.1  alpha-2,8-sialyltransferase 8F isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:13240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_024447976.1XP_024303744.1  alpha-2,8-sialyltransferase 8F isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:13240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_024447978.1XP_024303746.1  alpha-2,8-sialyltransferase 8F isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:13240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_017016175.1XP_016871664.1  alpha-2,8-sialyltransferase 8F isoform X2

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