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Kr-h2 Kruppel homolog 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33859, updated on 6-Jul-2026
Official Symbol
Kr-h2provided by FlyBase
Official Full Name
Kruppel homolog 2provided by FlyBase
Primary source
FLYBASE:FBgn0266449
Locus tag
Dmel_CG9159
See related
AllianceGenome:FB:FBgn0266449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-26Ba; CG9159; Dmel\CG9159; Kr-h; Kr-H2
Summary
Predicted to be involved in endoplasmic reticulum tubular network organization and membrane organization. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Kr-h2 in Genome Data Viewer
Location:
26B4-26B4; 2-18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6070990..6073961)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6070990..6073961)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Prefoldin 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43801 Neighboring gene long non-coding RNA:CR9162

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Krüppel homolog (Kr h) is a dosage-dependent modifier of gene expression in Drosophila. Benevolenskaya EV, et al. Genet Res, 2000 Apr. PMID 10816971
  2. Endoplasmic reticulum patterns insect cuticle nanostructure. Inagaki S, et al. J Cell Biol, 2026 Feb 2. PMID 41474612, Free PMC Article
  3. Chromatin topology is coupled to Polycomb group protein subnuclear organization. Wani AH, et al. Nat Commun, 2016 Jan 13. PMID 26759081, Free PMC Article
  4. Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. DeSalvo MK, et al. Glia, 2011 Sep. PMID 21351158, Free PMC Article
  5. Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo. Markstein M, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11752406, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
kruppel homolog 2
Names
CG9159-PA
CG9159-PB
CG9159-PC
Kr-h2-PA
Kr-h2-PB
Kr-h2-PC
anon-26Ba
kruppel homolog

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6070990..6073961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078766.3 → NP_523490.1  kruppel homolog 2, isoform A

    See identical proteins and their annotated locations for NP_523490.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0PV57, E1JHA1, Q9V447
    UniProtKB/TrEMBL
    X2J4W8
    Related
    FBpp0078823
    Conserved Domains (1) summary
    pfam03661
    Location:39 → 268
    UPF0121; uncharacterized protein family (UPF0121)

  2. NM_001298734.1 → NP_001285663.1  kruppel homolog 2, isoform C

    See identical proteins and their annotated locations for NP_001285663.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0PV57, E1JHA1, Q9V447
    UniProtKB/TrEMBL
    X2J4W8
    Conserved Domains (1) summary
    pfam03661
    Location:39 → 268
    UPF0121; uncharacterized protein family (UPF0121)

  3. NM_001169423.1 → NP_001162894.1  kruppel homolog 2, isoform B

    See identical proteins and their annotated locations for NP_001162894.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0PV57, E1JHA1, Q9V447
    UniProtKB/TrEMBL
    X2J4W8
    Conserved Domains (1) summary
    pfam03661
    Location:39 → 268
    UPF0121; uncharacterized protein family (UPF0121)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V447.1 Q9V447
X2J4W8 X2J4W8

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