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KCNK18 potassium two pore domain channel subfamily K member 18 [ Homo sapiens (human) ]

Gene ID: 338567, updated on 2-Mar-2021

Summary

Official Symbol
KCNK18provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 18provided by HGNC
Primary source
HGNC:HGNC:19439
See related
Ensembl:ENSG00000186795 MIM:613655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIK; MGR13; TRESK; TRESK2; K2p18.1; TRESK-2
Summary
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KCNK18 in Genome Data Viewer
Location:
10q25.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (117197489..117210299)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118957000..118969810)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MIR3663 host gene Neighboring gene microRNA 3663 Neighboring gene ribosomal protein L12 pseudogene 26 Neighboring gene uncharacterized LOC105378500 Neighboring gene solute carrier family 18 member A2 Neighboring gene PDZ domain containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
outward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to pH IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 18
Names
TWIK-related individual K+ channel
TWIK-related individual potassium channel
TWIK-related spinal cord K+ channel
TWIK-related spinal cord potassium channel
potassium channel, subfamily K, member 18
potassium channel, two pore domain subfamily K, member 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028085.1 RefSeqGene

    Range
    5001..17811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181840.1NP_862823.1  potassium channel subfamily K member 18

    See identical proteins and their annotated locations for NP_862823.1

    Status: REVIEWED

    Source sequence(s)
    AB087138
    Consensus CDS
    CCDS7598.1
    UniProtKB/Swiss-Prot
    Q7Z418
    Related
    ENSP00000334650.1, ENST00000334549.1
    Conserved Domains (1) summary
    pfam07885
    Location:100155
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    117197489..117210299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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