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FFAR4 free fatty acid receptor 4 [ Homo sapiens (human) ]

Gene ID: 338557, updated on 12-Sep-2021

Summary

Official Symbol
FFAR4provided by HGNC
Official Full Name
free fatty acid receptor 4provided by HGNC
Primary source
HGNC:HGNC:19061
See related
Ensembl:ENSG00000186188 MIM:609044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GT01; PGR4; BMIQ10; GPR120; GPR129; O3FAR1
Summary
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Biased expression in colon (RPKM 6.8), fat (RPKM 2.6) and 2 other tissues See more
Orthologs
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Genomic context

See FFAR4 in Genome Data Viewer
Location:
10q23.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (93566178..93590072)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95326422..95349829)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene centrosomal protein 55 Neighboring gene RNA, 5S ribosomal pseudogene 323 Neighboring gene uncharacterized LOC105378436 Neighboring gene retinol binding protein 4 Neighboring gene phosphodiesterase 6C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Body mass index quantitative trait locus 10
MedGen: C2675659 OMIM: 607514 GeneReviews: Not available
Compare labs
Genome-wide association study of circulating retinol levels.
GeneReviews: Not available

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC119984, DKFZp686F0824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in detection of chemical stimulus involved in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
involved_in ghrelin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of somatostatin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
free fatty acid receptor 4
Names
G-protein coupled receptor 120
G-protein coupled receptor 129
G-protein coupled receptor GT01
G-protein coupled receptor PGR4
omega-3 fatty acid receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032670.1 RefSeqGene

    Range
    5001..28408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195755.2NP_001182684.1  free fatty acid receptor 4 isoform GPR120-S

    See identical proteins and their annotated locations for NP_001182684.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (GPR120-S) lacking a 16 aa protein segment compared to isoform GPR120-L.
    Source sequence(s)
    AI469384, AI732606, AK301525, AL356214, BC101175, BM757151, DA986310
    Consensus CDS
    CCDS55720.1
    UniProtKB/Swiss-Prot
    Q5NUL3
    UniProtKB/TrEMBL
    B4DWG6
    Related
    ENSP00000360536.5, ENST00000371481.9
    Conserved Domains (1) summary
    cd00637
    Location:43321
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
  2. NM_181745.4NP_859529.2  free fatty acid receptor 4 isoform GPR120-L

    See identical proteins and their annotated locations for NP_859529.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (GPR120-L).
    Source sequence(s)
    AI469384, AI732606, AK301525, AL356214, AY288417, BC101175, BM757151, DA986310
    Consensus CDS
    CCDS31248.1
    UniProtKB/Swiss-Prot
    Q5NUL3
    UniProtKB/TrEMBL
    B4DWG6
    Related
    ENSP00000360538.4, ENST00000371483.8
    Conserved Domains (1) summary
    pfam00001
    Location:73337
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    93566178..93590072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539746.3XP_011538048.1  free fatty acid receptor 4 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:73233
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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