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FFAR4 free fatty acid receptor 4 [ Homo sapiens (human) ]

Gene ID: 338557, updated on 30-Apr-2020

Summary

Official Symbol
FFAR4provided by HGNC
Official Full Name
free fatty acid receptor 4provided by HGNC
Primary source
HGNC:HGNC:19061
See related
Ensembl:ENSG00000186188 MIM:609044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GT01; PGR4; BMIQ10; GPR120; GPR129; O3FAR1
Summary
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Biased expression in colon (RPKM 6.8), fat (RPKM 2.6) and 2 other tissues See more
Orthologs

Genomic context

See FFAR4 in Genome Data Viewer
Location:
10q23.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (93566178..93590072)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95326422..95349829)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene centrosomal protein 55 Neighboring gene RNA, 5S ribosomal pseudogene 323 Neighboring gene uncharacterized LOC105378436 Neighboring gene retinol binding protein 4 Neighboring gene phosphodiesterase 6C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Body mass index quantitative trait locus 10
MedGen: C2675659 OMIM: 607514 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of circulating retinol levels.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC119984, DKFZp686F0824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of chemical stimulus involved in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
ghrelin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of somatostatin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
free fatty acid receptor 4
Names
G-protein coupled receptor 120
G-protein coupled receptor 129
G-protein coupled receptor GT01
G-protein coupled receptor PGR4
omega-3 fatty acid receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032670.1 RefSeqGene

    Range
    5001..28408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195755.2NP_001182684.1  free fatty acid receptor 4 isoform GPR120-S

    See identical proteins and their annotated locations for NP_001182684.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (GPR120-S) lacking a 16 aa protein segment compared to isoform GPR120-L.
    Source sequence(s)
    AI469384, AI732606, AK301525, AL356214, BC101175, BM757151, DA986310
    Consensus CDS
    CCDS55720.1
    UniProtKB/Swiss-Prot
    Q5NUL3
    UniProtKB/TrEMBL
    B4DWG6
    Related
    ENSP00000360536.4, ENST00000371481.8
    Conserved Domains (1) summary
    cd00637
    Location:43321
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
  2. NM_181745.4NP_859529.2  free fatty acid receptor 4 isoform GPR120-L

    See identical proteins and their annotated locations for NP_859529.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (GPR120-L).
    Source sequence(s)
    AI469384, AI732606, AK301525, AL356214, AY288417, BC101175, BM757151, DA986310
    Consensus CDS
    CCDS31248.1
    UniProtKB/Swiss-Prot
    Q5NUL3
    UniProtKB/TrEMBL
    B4DWG6
    Related
    ENSP00000360538.4, ENST00000371483.8
    Conserved Domains (1) summary
    pfam00001
    Location:73337
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    93566178..93590072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539746.3XP_011538048.1  free fatty acid receptor 4 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:73233
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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