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Morc3 microrchidia 3 [ Mus musculus (house mouse) ]

Gene ID: 338467, updated on 12-May-2024

Summary

Official Symbol
Morc3provided by MGI
Official Full Name
microrchidia 3provided by MGI
Primary source
MGI:MGI:2136841
See related
Ensembl:ENSMUSG00000039456 AllianceGenome:MGI:2136841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NXP2; Zcwcc3; D16Jhu32e; 1110051N18Rik
Summary
Predicted to enable methylated histone binding activity. Acts upstream of or within post-embryonic development. Located in PML body. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human MORC3 (MORC family CW-type zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.1), CNS E11.5 (RPKM 7.9) and 27 other tissues See more
Orthologs
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Genomic context

See Morc3 in Genome Data Viewer
Location:
16 C4; 16 54.88 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (93629009..93672964)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (93832121..93876077)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5562 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:93711280-93711389 Neighboring gene STARR-positive B cell enhancer ABC_E1497 Neighboring gene STARR-seq mESC enhancer starr_41539 Neighboring gene predicted gene, 41501 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene RIKEN cDNA 2310043M15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:93798797-93799098 Neighboring gene STARR-positive B cell enhancer ABC_E7479 Neighboring gene STARR-seq mESC enhancer starr_41543 Neighboring gene predicted gene, 30881 Neighboring gene STARR-positive B cell enhancer ABC_E7480 Neighboring gene STARR-positive B cell enhancer ABC_E3176 Neighboring gene STARR-seq mESC enhancer starr_41545 Neighboring gene STARR-positive B cell enhancer ABC_E3177 Neighboring gene STARR-seq mESC enhancer starr_41548 Neighboring gene chromatin assembly factor 1, subunit B Neighboring gene STARR-positive B cell enhancer mm9_chr16:93914500-93914801 Neighboring gene STARR-positive B cell enhancer ABC_E10925 Neighboring gene STARR-seq mESC enhancer starr_41549 Neighboring gene claudin 14 Neighboring gene predicted gene, 31012

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MORC family CW-type zinc finger protein 3
Names
nuclear matrix protein 2
zinc finger CW-type coiled-coil domain protein 3
zinc finger, CW-type with coiled-coil domain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045529.3NP_001038994.2  MORC family CW-type zinc finger protein 3

    Status: VALIDATED

    Source sequence(s)
    AK172896, BC098072
    Consensus CDS
    CCDS79490.1
    UniProtKB/Swiss-Prot
    A6H605, F7BJB9, Q4QQR6, Q6A0C2, Q8R0R0
    Related
    ENSMUSP00000144369.2, ENSMUST00000202261.5
    Conserved Domains (4) summary
    pfam07496
    Location:409446
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:29136
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl09111
    Location:768875
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl21462
    Location:698721
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    93629009..93672964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523060.4XP_006523123.1  MORC family CW-type zinc finger protein 3 isoform X1

    Conserved Domains (4) summary
    TIGR02168
    Location:629810
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07496
    Location:340377
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:180313
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    cl00075
    Location:1466
    HATPase; Histidine kinase-like ATPase domain