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HCAR2 hydroxycarboxylic acid receptor 2 [ Homo sapiens (human) ]

Gene ID: 338442, updated on 22-Sep-2022

Summary

Official Symbol
HCAR2provided by HGNC
Official Full Name
hydroxycarboxylic acid receptor 2provided by HGNC
Primary source
HGNC:HGNC:24827
See related
Ensembl:ENSG00000182782 MIM:609163; AllianceGenome:HGNC:24827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A
Summary
Predicted to enable nicotinic acid receptor activity. Involved in neutrophil apoptotic process and positive regulation of neutrophil apoptotic process. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See HCAR2 in Genome Data Viewer
Location:
12q24.31
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (122701293..122703357, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (122696704..122698768, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123185840..123187904, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 9902-1 Neighboring gene microRNA 9902-2 Neighboring gene hydroxycarboxylic acid receptor 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nicotinic acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nicotinic acid receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neutrophil apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of adiponectin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neutrophil apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hydroxycarboxylic acid receptor 2
Names
G protein-coupled receptor HM74a
G-protein coupled receptor 109A
G-protein coupled receptor HM74A
hydroxy-carboxylic acid receptor 2
niacin receptor 1
nicotinic acid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177551.4NP_808219.1  hydroxycarboxylic acid receptor 2

    See identical proteins and their annotated locations for NP_808219.1

    Status: VALIDATED

    Source sequence(s)
    AL572062, AL698846, BC027965, BC056419, CD364466
    Consensus CDS
    CCDS9235.1
    UniProtKB/Swiss-Prot
    A7LGG3, Q8TDS4
    UniProtKB/TrEMBL
    A0A4Y1JWQ0
    Related
    ENSP00000375066.2, ENST00000328880.6
    Conserved Domains (1) summary
    cd15201
    Location:28305
    7tmA_HCAR1-3; hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    122701293..122703357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    122696704..122698768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)