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ANO9 anoctamin 9 [ Homo sapiens (human) ]

Gene ID: 338440, updated on 22-Sep-2022

Summary

Official Symbol
ANO9provided by HGNC
Official Full Name
anoctamin 9provided by HGNC
Primary source
HGNC:HGNC:20679
See related
Ensembl:ENSG00000185101 MIM:619963; AllianceGenome:HGNC:20679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIG5; TP53I5; TMEM16J
Summary
The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]
Expression
Broad expression in skin (RPKM 19.3), duodenum (RPKM 19.0) and 14 other tissues See more
Orthologs
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Genomic context

See ANO9 in Genome Data Viewer
Location:
11p15.5
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (417938..442011, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (463391..487355, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (417938..442011, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene plakophilin 3 Neighboring gene single Ig and TIR domain containing Neighboring gene uncharacterized LOC105376506 Neighboring gene RNA, 7SL, cytoplasmic 838, pseudogene Neighboring gene phosphatidylserine synthase 2 Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene leucine rich repeat containing 56

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anoctamin-9
Names
p53-induced gene 5 protein
transmembrane protein 16J
tumor protein p53-inducible protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052610.1 RefSeqGene

    Range
    5001..29074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012302.3NP_001012302.2  anoctamin-9 isoform 1

    See identical proteins and their annotated locations for NP_001012302.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC138230, AI986229, BC128557, DB140066
    Consensus CDS
    CCDS31326.1
    UniProtKB/Swiss-Prot
    A1A5B4, Q8TEN4
    Related
    ENSP00000332788.6, ENST00000332826.7
    Conserved Domains (2) summary
    pfam04547
    Location:179735
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:115176
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin
  2. NM_001347882.2NP_001334811.1  anoctamin-9 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC138230, KC877377
    Related
    ENST00000528927.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    417938..442011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    463391..487355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)