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TAS2R2 taste 2 receptor member 2 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 338396, updated on 7-Apr-2025

Summary

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Official Symbol
TAS2R2provided by HGNC
Official Full Name
taste 2 receptor member 2 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:20615
See related
Ensembl:ENSG00000203523 AllianceGenome:HGNC:20615
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PS9; T2R2; T2R02; TAS2R2P
Summary
Enables bitter taste receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of bitter taste. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
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Genomic context

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See TAS2R2 in Genome Data Viewer
Location:
7p21.3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (12491095..12492004)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (12622124..12623033)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (12530721..12531630)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375155 Neighboring gene CTAGE family member 5, ER export factor Neighboring gene uncharacterized LOC105375156 Neighboring gene small RNA binding exonuclease protection factor La like 5, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5173 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:12536548-12537176 Neighboring gene chromosome 7 open reading frame 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25664 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:12596820-12598019 Neighboring gene uncharacterized LOC107986768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25665 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:12635263-12636462 Neighboring gene scinderin Neighboring gene Sharpr-MPRA regulatory region 10361 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:12700000-12700549 Neighboring gene uncharacterized LOC105375157 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:12714709-12715908

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor. Lang T, et al. Mol Nutr Food Res, 2023 Jun. PMID 36929150, Free PMC Article
  2. A Matter of Taste: Lineage-Specific Loss of Function of Taste Receptor Genes in Vertebrates. Antinucci M, et al. Front Mol Biosci, 2017. PMID 29234667, Free PMC Article
  3. Genetic variation in taste receptor pseudogenes provides evidence for a dynamic role in human evolution. Risso D, et al. BMC Evol Biol, 2014 Sep 13. PMID 25216916, Free PMC Article
  4. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article
  5. Evolution of bitter taste receptors in humans and apes. Fischer A, et al. Mol Biol Evol, 2005 Mar. PMID 15496549

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Homology

Other Names

  • taste 2 receptor member 2, pseudogene
  • taste receptor Ps9 pseudogene
  • taste receptor, type 2, member 2, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005302.2 

    Range
    101..1010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    12491095..12492004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    12622124..12623033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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