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RAB7B RAB7B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 338382, updated on 28-Nov-2020

Summary

Official Symbol
RAB7Bprovided by HGNC
Official Full Name
RAB7B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:30513
See related
Ensembl:ENSG00000276600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB7
Expression
Broad expression in skin (RPKM 15.7), gall bladder (RPKM 6.5) and 20 other tissues See more
Orthologs
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Genomic context

See RAB7B in Genome Data Viewer
Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (205976740..206003470, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 9 Neighboring gene SLC26A9 and RAB7B antisense RNA 1 Neighboring gene uncharacterized LOC103021295 Neighboring gene cathepsin E Neighboring gene uncharacterized LOC105372857 Neighboring gene regulator of hemoglobinization and erythroid cell expansion

Genomic regions, transcripts, and products

Genomic Sequence:
NC_000001.11 Chromosome 1 Reference GRCh38.p13 Primary Assembly

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed
gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
gag HIV-1 Gag mainly remains in endosomes and co-localizes with endosomal protein Rab7 in the cycloheximide-treated cells PubMed
capsid gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9726, MGC16212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of toll-like receptor 4 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of toll-like receptor 9 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
phagosome-lysosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane TAS
Traceable Author Statement
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-7b
Names
Ras-related protein Rab-7
NP_001157994.1
NP_001291768.1
NP_796377.3
XP_006711351.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164522.3NP_001157994.1  ras-related protein Rab-7b isoform a

    See identical proteins and their annotated locations for NP_001157994.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AUXG01000006
    Consensus CDS
    CCDS73011.1
    UniProtKB/Swiss-Prot
    Q96AH8
    Related
    ENSP00000482499.1, ENST00000617070.5
    Conserved Domains (1) summary
    cd00154
    Location:9169
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
  2. NM_001304839.2NP_001291768.1  ras-related protein Rab-7b isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AUXG01000006
    Consensus CDS
    CCDS76258.1
    UniProtKB/TrEMBL
    A0A096LP44
    Related
    ENSP00000485386.1, ENST00000623893.1
    Conserved Domains (1) summary
    cd00154
    Location:9132
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
  3. NM_177403.6NP_796377.3  ras-related protein Rab-7b isoform a

    See identical proteins and their annotated locations for NP_796377.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AUXG01000006
    Consensus CDS
    CCDS73011.1
    UniProtKB/Swiss-Prot
    Q96AH8
    Related
    ENSP00000479762.1, ENST00000617991.4
    Conserved Domains (1) summary
    cd00154
    Location:9169
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    205976740..206003470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711288.4XP_006711351.1  ras-related protein Rab-7b isoform X1

    Conserved Domains (2) summary
    smart00175
    Location:9174
    RAB; Rab subfamily of small GTPases
    cd00154
    Location:9169
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
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