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IBSP integrin binding sialoprotein [ Homo sapiens (human) ]

Gene ID: 3381, updated on 8-Jul-2021

Summary

Official Symbol
IBSPprovided by HGNC
Official Full Name
integrin binding sialoproteinprovided by HGNC
Primary source
HGNC:HGNC:5341
See related
Ensembl:ENSG00000029559 MIM:147563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BSP; BNSP; SP-II; BSP-II
Summary
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IBSP in Genome Data Viewer
Location:
4q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (87799554..87812435)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88720706..88733587)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377324 Neighboring gene IBSP 5' regulatory region Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 7 Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene heat shock protein 90 alpha family class B member 3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.
GeneReviews: Not available
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of integrin-binding sialoprotein (IBSP) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular matrix organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in osteoblast differentiation HDA PubMed 
involved_in positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane HDA PubMed 
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
bone sialoprotein 2
Names
BSP II
bone sialoprotein II
cell-binding sialoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004967.4NP_004958.2  bone sialoprotein 2 precursor

    See identical proteins and their annotated locations for NP_004958.2

    Status: REVIEWED

    Source sequence(s)
    AA452255, AC093768, AI751848, BQ573754, DV462680, J05213
    Consensus CDS
    CCDS3624.1
    UniProtKB/Swiss-Prot
    P21815
    Related
    ENSP00000226284.5, ENST00000226284.7
    Conserved Domains (1) summary
    pfam05432
    Location:17314
    BSP_II; Bone sialoprotein II (BSP-II)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    87799554..87812435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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