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bsg basigin [ Danio rerio (zebrafish) ]

Gene ID: 337692, updated on 9-Sep-2025
Official Symbol
bsgprovided by ZNC
Official Full Name
basiginprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9638
See related
Ensembl:ENSDARG00000019881 AllianceGenome:ZFIN:ZDB-GENE-030131-9638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb26a05; wu:fo98e12
Summary
Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in basolateral plasma membrane and endoplasmic reticulum membrane. Predicted to be active in axon and plasma membrane. Is expressed in intestine and liver. Orthologous to human BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See bsg in Genome Data Viewer
Location:
chromosome: 22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 22 NC_133197.1 (18634790..18651832)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 22 NC_007133.7 (18929412..18946454)

Chromosome 22 - NC_133197.1Genomic Context describing neighboring genes Neighboring gene CACN subunit beta associated regulatory protein b Neighboring gene follistatin-like 3 (secreted glycoprotein) Neighboring gene uncharacterized LOC141380308 Neighboring gene hyperpolarization activated cyclic nucleotide-gated potassium channel 2b Neighboring gene polymerase (RNA) mitochondrial (DNA directed)

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Ochrietor JD, et al. Invest Ophthalmol Vis Sci, 2003 Sep. PMID 12939332
  2. Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages. Xie Y, et al. Front Immunol, 2021. PMID 34046029, Free PMC Article
  3. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Eichner R, et al. Nat Med, 2016 Jul. PMID 27294876
  4. The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Oehlers SH, et al. Dis Model Mech, 2011 Nov. PMID 21729873, Free PMC Article
  5. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. Manchenkov T, et al. G3 (Bethesda), 2015 Apr 3. PMID 25840431, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
basigin
Names
5A11/Basigin-2
cd147

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312882.1 → NP_001299811.1  basigin isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    DT058336, EH520368, EH536274, EH563077, JBMGRA010000022
    UniProtKB/TrEMBL
    A4JYP7, Q6PH44
    Related
    ENSDARP00000139566.1, ENSDART00000161598.2
    Conserved Domains (2) summary
    smart00410
    Location:118 → 209
    IG_like; Immunoglobulin like
    cl11960
    Location:111 → 199
    Ig; Immunoglobulin domain

  2. NM_198142.2 → NP_937785.2  basigin isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CK356411, DT058336, EH520368, EH536274, EH563077, JBMGRA010000022
    UniProtKB/TrEMBL
    A0A0R4ICR8, A0A8M1PDN1
    Related
    ENSDARP00000130496.1, ENSDART00000166650.3
    Conserved Domains (2) summary
    smart00410
    Location:235 → 326
    IG_like; Immunoglobulin like
    cl11960
    Location:38 → 114
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133197.1 Reference GRCz12tu Primary Assembly

    Range
    18634790..18651832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296228.4 → XP_009294503.1  basigin isoform X1

    UniProtKB/TrEMBL
    A0A8M3AUM8
    Conserved Domains (2) summary
    smart00410
    Location:235 → 326
    IG_like; Immunoglobulin like
    cl11960
    Location:38 → 114
    Ig; Immunoglobulin domain

  2. XM_073936300.1 → XP_073792401.1  basigin isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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