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Acsf2 Acyl-CoA synthetase family member 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33766, updated on 4-Apr-2024

Summary

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Official Symbol
Acsf2provided by FlyBase
Official Full Name
Acyl-CoA synthetase family member 2provided by FlyBase
Primary source
FLYBASE:FBgn0031703
Locus tag
Dmel_CG12512
See related
AllianceGenome:FB:FBgn0031703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACSF2; CG12512; Dmel\CG12512
Summary
Predicted to enable medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in peroxisome. Is expressed in adult head. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Acsf2 in Genome Data Viewer
Location:
25D6-25D6; 2-16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5339132..5342234, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5339132..5342234, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Turandot M Neighboring gene fuseless Neighboring gene no mechanoreceptor potential C Neighboring gene long non-coding RNA:CR42850

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear translocation ability of Lipin differentially affects gene expression and survival in fed and fasting Drosophila. Hood SE, et al. J Lipid Res, 2020 Dec. PMID 32989002, Free PMC Article
  2. Active promoters and insulators are marked by the centrosomal protein 190. Bartkuhn M, et al. EMBO J, 2009 Apr 8. PMID 19229299, Free PMC Article
  3. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
  4. Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Yoon WH, et al. Neuron, 2017 Jan 4. PMID 28017472, Free PMC Article
  5. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables CoA-ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables fatty acid ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables medium-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Acyl-CoA synthetase family member 2
Names
Acsf2-PA
CG12512-PA
NP_608924.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5339132..5342234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135080.3 → NP_608924.1  Acyl-CoA synthetase family member 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608924.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMR6
    Related
    FBpp0078711
    Conserved Domains (2) summary
    cd05917
    Location:229 → 577
    FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
    PRK08315
    Location:43 → 592
    PRK08315; AMP-binding domain protein; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMR6 Q9VMR6

Gene LinkOut

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