dcaf7 ddb1 and cul4 associated factor 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dcaf7provided by ZNC
Official Full Name: ddb1 and cul4 associated factor 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9511
See related: Ensembl:ENSDARG00000054355 AllianceGenome:ZFIN:ZDB-GENE-030131-9511
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wdr68; han11l; fj83g06; zgc:63940; wu:fj83g06
Summary: Acts upstream of or within cartilage development and embryonic viscerocranium morphogenesis. Located in nucleus. Is expressed in forebrain; head; hindbrain; and somite. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	3	NC_133178.1 (30508027..30517680)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (31717296..31726949)

Chromosome 3 - NC_133178.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings reveal an indirect role for Wdr68 in the BMP-Edn1-Jag1b signaling hierarchy and dorso-anterior expression of dlx1a/2a.
Title: Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial Development.
we show that while a GFP-Wdr68 fusion functionally substituted for craniofacial development in the zebrafish, that a Nuclear Export Signal (NES) fusion protein (GFPNESWdr68) failed to support craniofacial development
Title: Wdr68 requires nuclear access for craniofacial development.
The initial characterization of wdr68 suggests an important role in craniofacial development for the highly conserved Wdr68-Dyrk1 protein complexes.
Title: A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression.

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General gene information

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Markers

G39723 (e-PCR)
- UniSTS:69959

fj83g06.x1 (e-PCR)
- UniSTS:200059

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 7

Names: AN11 homolog; WD repeat domain 68; dirty south; dys

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200069.1 → NP_956363.1 DDB1- and CUL4-associated factor 7

See identical proteins and their annotated locations for NP_956363.1

Status: PROVISIONAL

Source sequence(s)

BC053157

UniProtKB/TrEMBL

A0A8M1PAP9, Q7T3E0

Related

ENSDARP00000058220.6, ENSDART00000058221.7

Conserved Domains (2) summary

sd00039
Location:19 → 66

7WD40; WD40 repeat [structural motif]

cl29593
Location:19 → 295

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...