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bcat1 branched chain amino-acid transaminase 1, cytosolic [ Danio rerio (zebrafish) ]

Gene ID: 337412, updated on 2-Nov-2024

Summary

Official Symbol
bcat1provided by ZNC
Official Full Name
branched chain amino-acid transaminase 1, cytosolicprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9358
See related
Ensembl:ENSDARG00000045568 AllianceGenome:ZFIN:ZDB-GENE-030131-9358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj66g02; zgc:73157; wu:fj66g02
Summary
Predicted to enable branched-chain-amino-acid transaminase activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within amino acid biosynthetic process and branched-chain amino acid biosynthetic process. Predicted to be active in mitochondrion. Is expressed in central nervous system; liver; muscle; and neural tube. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See bcat1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17279966..17297431)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17290953..17308444)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491539 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene lymphoid-restricted membrane protein Neighboring gene insulin-like growth factor 1 Neighboring gene nucleoporin 37 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin-concentrating hormone

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-isoleucine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-leucine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-valine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables branched-chain-amino-acid transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables branched-chain-amino-acid transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within branched-chain amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
branched-chain-amino-acid aminotransferase, cytosolic
Names
branched chain aminotransferase 1, cytosolic
NP_956358.1
XP_005164772.1
XP_009298529.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200064.1NP_956358.1  branched-chain-amino-acid aminotransferase, cytosolic

    See identical proteins and their annotated locations for NP_956358.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059513
    UniProtKB/TrEMBL
    Q6PC10
    Related
    ENSDARP00000067004.3, ENSDART00000067005.5
    Conserved Domains (2) summary
    PRK13357
    Location:36378
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:81375
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    17279966..17297431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009300254.4XP_009298529.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X1

    UniProtKB/TrEMBL
    A0A8M3AYQ7
    Conserved Domains (2) summary
    PRK13357
    Location:26368
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:71365
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
  2. XM_005164715.5XP_005164772.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X2

    UniProtKB/TrEMBL
    A0A8M2BBX5
    Conserved Domains (2) summary
    PRK13357
    Location:24366
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:69363
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...