Format

Send to:

Choose Destination

APOA4 apolipoprotein A4 [ Homo sapiens (human) ]

Gene ID: 337, updated on 28-Nov-2021

Summary

Official Symbol
APOA4provided by HGNC
Official Full Name
apolipoprotein A4provided by HGNC
Primary source
HGNC:HGNC:602
See related
Ensembl:ENSG00000110244 MIM:107690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward small intestine (RPKM 1486.2) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See APOA4 in Genome Data Viewer
Location:
11q23.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (116820700..116823304, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (116691416..116694020, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ZPR1 zinc finger Neighboring gene enhancer-blocking element 11-1-2 overlapping APOA5 Neighboring gene apolipoprotein A5 Neighboring gene skeletal muscle cis-regulatory module in APOA4 and APOC3 intergenic region Neighboring gene apolipoprotein C3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
GeneReviews: Not available
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
GeneReviews: Not available
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Common variants at 30 loci contribute to polygenic dyslipidemia.
GeneReviews: Not available
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
GeneReviews: Not available
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
GeneReviews: Not available
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
GeneReviews: Not available
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
GeneReviews: Not available
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
GeneReviews: Not available
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
GeneReviews: Not available
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142154, MGC142156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lipid transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylcholine-sterol O-acyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine-sterol O-acyltransferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chylomicron assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in chylomicron remodeling IC
Inferred by Curator
more info
PubMed 
involved_in high-density lipoprotein particle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in high-density lipoprotein particle remodeling IC
Inferred by Curator
more info
PubMed 
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response in mucosa IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of plasma lipoprotein oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peripheral nervous system axon regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cholesterol esterification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cholesterol esterification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of lipoprotein lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of triglyceride catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-lipid complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of intestinal cholesterol absorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in removal of superoxide radicals IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipid hydroperoxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to stilbenoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to triglyceride IEA
Inferred from Electronic Annotation
more info
 
involved_in reverse cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reverse cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in very-low-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in very-low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
apolipoprotein A-IV
Names
apo-AIV
apoA-IV

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012044.1 RefSeqGene

    Range
    4992..7596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000482.4NP_000473.2  apolipoprotein A-IV precursor

    See identical proteins and their annotated locations for NP_000473.2

    Status: REVIEWED

    Source sequence(s)
    AL531739, AP006216
    Consensus CDS
    CCDS31681.1
    Related
    ENSP00000350425.3, ENST00000357780.5
    Conserved Domains (1) summary
    pfam01442
    Location:66235
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    116820700..116823304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center