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APOA4 apolipoprotein A4 [ Homo sapiens (human) ]

Gene ID: 337, updated on 24-Nov-2020

Summary

Official Symbol
APOA4provided by HGNC
Official Full Name
apolipoprotein A4provided by HGNC
Primary source
HGNC:HGNC:602
See related
Ensembl:ENSG00000110244 MIM:107690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward small intestine (RPKM 1486.2) See more
Orthologs

Genomic context

See APOA4 in Genome Data Viewer
Location:
11q23.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (116820700..116823304, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (116691418..116694011, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ZPR1 zinc finger Neighboring gene enhancer-blocking element 11-1-2 overlapping APOA5 Neighboring gene apolipoprotein A5 Neighboring gene skeletal muscle cis-regulatory module in APOA4 and APOC3 intergenic region Neighboring gene apolipoprotein C3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
GeneReviews: Not available
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
GeneReviews: Not available
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Common variants at 30 loci contribute to polygenic dyslipidemia.
GeneReviews: Not available
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
GeneReviews: Not available
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
GeneReviews: Not available
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
GeneReviews: Not available
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
GeneReviews: Not available
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
GeneReviews: Not available
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
GeneReviews: Not available
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142154, MGC142156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid transporter activity TAS
Traceable Author Statement
more info
PubMed 
phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine-sterol O-acyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine-sterol O-acyltransferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
chylomicron assembly TAS
Traceable Author Statement
more info
PubMed 
chylomicron remodeling IC
Inferred by Curator
more info
PubMed 
chylomicron remodeling TAS
Traceable Author Statement
more info
 
high-density lipoprotein particle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle remodeling IC
Inferred by Curator
more info
PubMed 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response in mucosa IDA
Inferred from Direct Assay
more info
PubMed 
intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
lipid transport IDA
Inferred from Direct Assay
more info
PubMed 
lipoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of plasma lipoprotein oxidation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid efflux IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol esterification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cholesterol esterification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of lipoprotein lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of triglyceride catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein-lipid complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of intestinal cholesterol absorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
removal of superoxide radicals IDA
Inferred from Direct Assay
more info
PubMed 
response to lipid hydroperoxide IDA
Inferred from Direct Assay
more info
PubMed 
response to stilbenoid IEA
Inferred from Electronic Annotation
more info
 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
reverse cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
reverse cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very-low-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very-low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
colocalizes_with cell surface IDA
Inferred from Direct Assay
more info
PubMed 
chylomicron IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chylomicron IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
cytosol TAS
Traceable Author Statement
more info
 
early endosome TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
apolipoprotein A-IV
Names
apo-AIV
apoA-IV

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012044.1 RefSeqGene

    Range
    4992..7596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000482.4NP_000473.2  apolipoprotein A-IV precursor

    See identical proteins and their annotated locations for NP_000473.2

    Status: REVIEWED

    Source sequence(s)
    AL531739, AP006216
    Consensus CDS
    CCDS31681.1
    Related
    ENSP00000350425.3, ENST00000357780.5
    Conserved Domains (3) summary
    pfam01442
    Location:66235
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam06386
    Location:170275
    GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
    cl02073
    Location:76219
    DUF3422; Protein of unknown function (DUF3422)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    116820700..116823304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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