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chek2 checkpoint kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 336998, updated on 14-Feb-2019

Summary

Official Symbol
chek2provided by ZNC
Official Full Name
checkpoint kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8942
See related
Ensembl:ENSDARG00000025820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
fa66f08; zgc:55865; wu:fa66f08
Orthologs

Genomic context

See chek2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (10055991..10082239, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (9551342..9577601, complement)
103 previous assembly Zv9 (GCF_000002035.4) 5 NC_007116.5 (10963593..10989864, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC799523 Neighboring gene solute carrier family 2 member 11b Neighboring gene glutathione S-transferase theta 2 Neighboring gene si:ch211-207k7.4 Neighboring gene uncharacterized LOC108190050

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
mitotic DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase Chk2
NP_956339.1
XP_005165087.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200045.1NP_956339.1  serine/threonine-protein kinase Chk2

    See identical proteins and their annotated locations for NP_956339.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044519
    UniProtKB/TrEMBL
    Q803E2
    Related
    ENSDARP00000036490.6, ENSDART00000036421.7
    Conserved Domains (3) summary
    smart00220
    Location:193456
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:72174
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:186456
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    10055991..10082239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165030.4XP_005165087.1  serine/threonine-protein kinase Chk2 isoform X1

    Conserved Domains (4) summary
    smart00220
    Location:193456
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1716
    Location:73173
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:72174
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:186456
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394566.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    195199..223751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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