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cdc42 cell division cycle 42 [ Danio rerio (zebrafish) ]

Gene ID: 336839, updated on 9-Sep-2025
Official Symbol
cdc42provided by ZNC
Official Full Name
cell division cycle 42provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8783
See related
Ensembl:ENSDARG00000044573 AllianceGenome:ZFIN:ZDB-GENE-030131-8783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cdc42a; fj62g06; zgc:63918; wu:fb07d08; wu:fj62g06
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in cell surface receptor signaling pathway; positive regulation of cell migration involved in sprouting angiogenesis; and positive regulation of filopodium assembly. Acts upstream of or within several processes, including camera-type eye development; melanosome transport; and plasma membrane bounded cell projection assembly. Predicted to be located in cytoplasm; membrane; and midbody. Predicted to be active in plasma membrane. Is expressed in blastodisc; brain; eye; primordial germ cell; and pronephros. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See cdc42 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 11 NC_133186.1 (41545979..41573878)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 11 NC_007122.7 (39120299..39148203)

Chromosome 11 - NC_133186.1Genomic Context describing neighboring genes Neighboring gene zgc:112255 Neighboring gene adaptor related protein complex 5 subunit beta 1 Neighboring gene wingless-type MMTV integration site family, member 4 Neighboring gene uncharacterized LOC108191631

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Cdc42 and sec10 Are Required for Normal Retinal Development in Zebrafish. Choi SY, et al. Invest Ophthalmol Vis Sci, 2015 May. PMID 26024121, Free PMC Article
  2. Determination of dissociation constants in living zebrafish embryos with single wavelength fluorescence cross-correlation spectroscopy. Shi X, et al. Biophys J, 2009 Jul 22. PMID 19619483, Free PMC Article
  3. RhoA/ROCK pathway activity is essential for the correct localization of the germ plasm mRNAs in zebrafish embryos. Miranda-Rodríguez JR, et al. Dev Biol, 2017 Jan 1. PMID 27836552
  4. dock8 deficiency attenuates microglia colonization in early zebrafish larvae. Wu L, et al. Cell Death Discov, 2022 Aug 17. PMID 35977943, Free PMC Article
  5. Cdc42 deficiency causes ciliary abnormalities and cystic kidneys. Choi SY, et al. J Am Soc Nephrol, 2013 Sep. PMID 23766535, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
    Title: Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
  2. Maternal miR-202-5p is required for zebrafish primordial germ cell migration by protecting small GTPase Cdc42.
    Title: Maternal miR-202-5p is required for zebrafish primordial germ cell migration by protecting small GTPase Cdc42.
  3. Knockdown of fat1 in zebrafish causes pronephric cysts, which is partially rescued by RAC1/CDC42 activators, confirming a role of the two small GTPases in the pathogenesis.
    Title: FAT1 mutations cause a glomerulotubular nephropathy.
  4. Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
    Title: Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
  5. Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm.
    Title: Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm.
  6. These results suggest that Ptenb by antagonizing PI3 kinase and its downstream Akt1 and Cdc42 to regulate actin polymerization that is critical for proper cell motility and migration control during gastrulation in zebrafish.
    Title: Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC63918

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within camera-type eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within melanosome transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within melanosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microglial cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cell division control protein 42 homolog
Names
Cdc42 protein homolog
NP_001018130.1
NP_956926.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018120.2 → NP_001018130.1  cell division control protein 42 homolog isoform 2

    See identical proteins and their annotated locations for NP_001018130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    JBMGRA010000011
    UniProtKB/TrEMBL
    A0A8M1N5V7, Q52WY2
    Related
    ENSDARP00000129719.1, ENSDART00000154158.2
    Conserved Domains (1) summary
    cd01874
    Location:3 → 177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

  2. NM_200632.2 → NP_956926.1  cell division control protein 42 homolog isoform 1

    See identical proteins and their annotated locations for NP_956926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    EH509759, JBMGRA010000011
    UniProtKB/TrEMBL
    A0A8M1PHH0, Q6PFU4
    Related
    ENSDARP00000129339.1, ENSDART00000155746.3
    Conserved Domains (1) summary
    cd01874
    Location:3 → 177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133186.1 Reference GRCz12tu Primary Assembly

    Range
    41545979..41573878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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