Elba1 Early boundary activity 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Elba1provided by FlyBase
Official Full Name: Early boundary activity 1provided by FlyBase
Primary source: FLYBASE:FBgn0000227
Locus tag: Dmel_CG12205
See related: AllianceGenome:FB:FBgn0000227
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.70; bsg25A; Bsg25A; CG12205; clone 1.70; Dmel\CG12205; Elba; elba1
Summary: Contributes to chromatin insulator sequence binding activity and sequence-specific DNA binding activity. Involved in embryonic development via the syncytial blastoderm and heterochromatin boundary formation. Located in nucleus. Part of chromatin silencing complex. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; and ectoderm anlage. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Try the new Transcripts and proteins table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4683052..4684461, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4683052..4684461, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Stress-sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis.
Title: Stress-sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis.
Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.
Title: Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
contributes_to chromatin insulator sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin insulator sequence binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryonic development via the syncytial blastoderm	IEP Inferred from Expression Pattern more info	PubMed
involved_in heterochromatin boundary formation	IDA Inferred from Direct Assay more info	PubMed
involved_in heterochromatin boundary formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin silencing complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin silencing complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info