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CG3355 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33667, updated on 6-Jul-2026
Official Symbol
CG3355provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031619
Locus tag
Dmel_CG3355
See related
AllianceGenome:FB:FBgn0031619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG3355; SP21
Summary
Enables serine hydrolase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in ventral sensory complex primordium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 8 and sensorineural hearing loss. Orthologous to several human genes including TMPRSS13 (transmembrane serine protease 13); TMPRSS2 (transmembrane serine protease 2); and TMPRSS3 (transmembrane serine protease 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See CG3355 in Genome Data Viewer
Location:
25A2-25A2; 2-13 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4651403..4652892)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4651403..4652892)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long noncoding RNA: testis-specific 6 Neighboring gene uncharacterized protein Neighboring gene Early boundary activity 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. In Drosophila Hemolymph, Serine Proteases Are the Major Gelatinases and Caseinases. Gatti JL, et al. Insects, 2024 Mar 28. PMID 38667364, Free PMC Article
  2. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development. Rice C, et al. Genetics, 2020 Dec. PMID 33115752, Free PMC Article
  3. The female-specific doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. Chatterjee SS, et al. Development, 2011 Mar. PMID 21343364
  4. Transcriptome Analysis of Drosophila melanogaster Third Instar Larval Ring Glands Points to Novel Functions and Uncovers a Cytochrome p450 Required for Development. Christesen D, et al. G3 (Bethesda), 2017 Feb 9. PMID 27974438, Free PMC Article
  5. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
uncharacterized protein
Names
CG3355-PA
CG3355-PB
NP_608848.1
NP_723001.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4651403..4652892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164594.1 → NP_723001.1  uncharacterized protein Dmel_CG3355, isoform B

    See identical proteins and their annotated locations for NP_723001.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PDW5, Q8MT30
    Conserved Domains (2) summary
    smart00020
    Location:75 → 201
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:76 → 201
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_135004.2 → NP_608848.1  uncharacterized protein Dmel_CG3355, isoform A

    See identical proteins and their annotated locations for NP_608848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBX7, Q9VR15
    Related
    FBpp0077068
    Conserved Domains (2) summary
    smart00020
    Location:75 → 302
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:76 → 305
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2PDW5 Q2PDW5
Q8MT30 Q8MT30
Q9VR15 Q9VR15

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