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tarbp2 TAR (HIV) RNA binding protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 336141, updated on 8-Mar-2025

Summary

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Official Symbol
tarbp2provided by ZNC
Official Full Name
TAR (HIV) RNA binding protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8085
See related
Ensembl:ENSDARG00000070471 AllianceGenome:ZFIN:ZDB-GENE-030131-8085
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj51e12; zgc:63778; wu:fj51e12
Summary
Predicted to enable double-stranded RNA binding activity and siRNA binding activity. Predicted to be involved in regulation of regulatory ncRNA processing and siRNA processing. Predicted to act upstream of or within regulation of gene expression and regulation of viral transcription. Predicted to be part of RISC complex and RISC-loading complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human TARBP2 (TARBP2 subunit of RISC loading complex). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
human mouse all
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Genomic context

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See tarbp2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (46725540..46735380, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (46723658..46733498, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene oxytocin receptor b Neighboring gene thymocyte expressed, positive selection associated 1 Neighboring gene zgc:66479 Neighboring gene immunoglobulin like and fibronectin type III domain containing 1, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka. Yu T, et al. Development, 2017 Jan 15. PMID 27993982
  2. Cloning, expression, and characterization of the zebrafish Dicer and Drosha enzymes. Li P, et al. Biochem Biophys Res Commun, 2019 Jun 18. PMID 31029426
  3. Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Beaudoin JD, et al. Nat Struct Mol Biol, 2018 Aug. PMID 30061596, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables miRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-miRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables siRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables siRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RISC complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in global gene silencing by mRNA cleavage IEA
Inferred from Electronic Annotation
more info
  
involved_in pre-miRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of miRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of regulatory ncRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of siRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of viral transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in siRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RISC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of RISC-loading complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RISC-loading complex IEA
Inferred from Electronic Annotation
more info
  
part_of RISC-loading complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RISC-loading complex subunit tarbp2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199997.1 → NP_956291.1  RISC-loading complex subunit tarbp2

    See identical proteins and their annotated locations for NP_956291.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055390
    UniProtKB/Swiss-Prot
    Q7SXR1
    Related
    ENSDARP00000094231.3, ENSDART00000103455.4
    Conserved Domains (3) summary
    smart00358
    Location:31 → 79
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:139 → 202
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:278 → 325
    Staufen_C; Staufen C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    46725540..46735380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SXR1.1 GenPept UniProtKB/Swiss-Prot:Q7SXR1

Gene LinkOut

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