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APOA2 apolipoprotein A2 [ Homo sapiens (human) ]

Gene ID: 336, updated on 5-Jul-2020

Summary

Official Symbol
APOA2provided by HGNC
Official Full Name
apolipoprotein A2provided by HGNC
Primary source
HGNC:HGNC:601
See related
Ensembl:ENSG00000158874 MIM:107670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
apoAII; Apo-AII; ApoA-II
Summary
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 5129.5) See more
Orthologs

Genomic context

See APOA2 in Genome Data Viewer
Location:
1q23.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161222292..161223628, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161192083..161193418, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene Fc fragment of IgE receptor Ig Neighboring gene translocase of outer mitochondrial membrane 40 like Neighboring gene microRNA 5187 Neighboring gene nuclear receptor subfamily 1 group I member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
apolipoprotein receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apolipoprotein receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
high-density lipoprotein particle binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to intermembrane cholesterol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
lipase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine-sterol O-acyltransferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chylomicron assembly TAS
Traceable Author Statement
more info
 
chylomicron remodeling TAS
Traceable Author Statement
more info
 
diacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle assembly IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
lipoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
low-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol import IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cholesterol transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytokine production involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of very-low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-methionine modification IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid efflux IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cholesterol esterification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein oxidation IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of intestinal cholesterol absorption IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of protein stability IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
reverse cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride metabolic process TAS
Traceable Author Statement
more info
PubMed 
triglyceride-rich lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride-rich lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
chylomicron IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chylomicron IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
early endosome TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle TAS
Traceable Author Statement
more info
PubMed 
spherical high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spherical high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012043.1 RefSeqGene

    Range
    5001..6337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001643.2NP_001634.1  apolipoprotein A-II preproprotein

    See identical proteins and their annotated locations for NP_001634.1

    Status: REVIEWED

    Source sequence(s)
    AL590714
    Consensus CDS
    CCDS1226.1
    UniProtKB/Swiss-Prot
    P02652
    Related
    ENSP00000356969.3, ENST00000367990.7
    Conserved Domains (1) summary
    pfam04711
    Location:2498
    ApoA-II; Apolipoprotein A-II (ApoA-II)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161222292..161223628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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