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pkma pyruvate kinase M1/2a [ Danio rerio (zebrafish) ]

Gene ID: 335817, updated on 12-Aug-2026
Official Symbol
pkmaprovided by ZNC
Official Full Name
pyruvate kinase M1/2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031201-4
See related
Ensembl:ENSDARG00000099730 AllianceGenome:ZFIN:ZDB-GENE-031201-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pkm2; pkm2a; cb1029; fj33f03; wu:fj33f03
Summary
Predicted to enable pyruvate kinase activity. Involved in sprouting angiogenesis. Predicted to be active in cytoplasm. Is expressed in several structures, including nervous system; neural tube; otic vesicle; pericardial region; and solid lens vesicle. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See pkma in Genome Data Viewer
Location:
chromosome: 18
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 18 NC_133193.1 (1521879..1567187)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 18 NC_007129.7 (911015..951570)

Chromosome 18 - NC_133193.1Genomic Context describing neighboring genes Neighboring gene CUGBP Elav-like family member 6 Neighboring gene poly (ADP-ribose) polymerase family, member 6a Neighboring gene dihydrodiol dehydrogenase, tandem duplicate 2 Neighboring gene dihydrodiol dehydrogenase, tandem duplicate 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration. Spelat R, et al. Commun Biol, 2022 Dec 13. PMID 36509839, Free PMC Article
  2. Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo. Lin J, et al. Cell Prolif, 2021 Aug. PMID 34240779, Free PMC Article
  3. Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Stone OA, et al. Nat Commun, 2018 Oct 9. PMID 30301887, Free PMC Article
  4. Metabolic modulation regulates cardiac wall morphogenesis in zebrafish. Fukuda R, et al. Elife, 2019 Dec 23. PMID 31868165, Free PMC Article
  5. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. Li Z, et al. PLoS One, 2015. PMID 26147004, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
pyruvate kinase PKM
Names
pyruvate kinase, muscle, a
NP_955365.1
XP_009291639.1
XP_073785020.1
XP_073785021.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199333.1 → NP_955365.1  pyruvate kinase PKM

    See identical proteins and their annotated locations for NP_955365.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045421
    UniProtKB/TrEMBL
    A0A8M1PBF2, B2GQD5, Q7ZVT2
    Related
    ENSDARP00000140346.1, ENSDART00000167229.3
    Conserved Domains (2) summary
    cd00288
    Location:43 → 531
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:44 → 528
    pyruv_kin; pyruvate kinase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133193.1 Reference GRCz12tu Primary Assembly

    Range
    1521879..1567187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073928919.1 → XP_073785020.1  pyruvate kinase PKM isoform X1

    UniProtKB/TrEMBL
    A0AC58HSQ6

  2. XM_073928920.1 → XP_073785021.1  pyruvate kinase PKM isoform X2

    UniProtKB/TrEMBL
    A0AC58HSQ3

  3. XM_009293364.4 → XP_009291639.1  pyruvate kinase PKM isoform X3

    UniProtKB/TrEMBL
    A0A0R4IGP6, A0A8M3ARR1
    Related
    ENSDARP00000132638.1
    Conserved Domains (2) summary
    cd00288
    Location:43 → 531
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:44 → 528
    pyruv_kin; pyruvate kinase
Nucleotide Protein Strain
Heading Accession and Version

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