nme2a NME/NM23 nucleoside diphosphate kinase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nme2aprovided by ZNC
Official Full Name: NME/NM23 nucleoside diphosphate kinase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7656
See related: Ensembl:ENSDARG00000043820 AllianceGenome:ZFIN:ZDB-GENE-030131-7656
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nme2l; zgc:73122; wu:fk59e05; si:ch211-119c20.1
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to act upstream of or within nucleotide metabolic process. Is expressed in several structures, including digestive system; female organism; gonad; male organism; and visual system. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1) and NME2 (NME/NM23 nucleoside diphosphate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (20788243..20796450, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (20666372..20674570, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NDPKB is required for VEGF-induced angiogenesis and contributes to the correct localization of VEGF receptor type 2 and VE-cadherin at the endothelial adherens junctions.
Title: Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NME/NM23 nucleoside diphosphate kinase 2a; nucleoside diphosphate kinase B

Names: non-metastatic cells 2-like, protein (NM23B) expressed in; non-metastatic cells 2a, protein (NM23B) expressed in; novel nucleoside-diphosphate kinase (wu:fk59e05); nucleoside diphosphate kinase A

NP_956264.1

EC 2.7.4.6

XP_021335706.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199970.2 → NP_956264.1 NME/NM23 nucleoside diphosphate kinase 2a

See identical proteins and their annotated locations for NP_956264.1

Status: VALIDATED

Source sequence(s)

BX004803

UniProtKB/TrEMBL

A0A8M1PC91, E7FBE9, Q6PC37

Related

ENSDARP00000064338.3, ENSDART00000064339.5

Conserved Domains (2) summary

PTZ00093
Location:4 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

pfam00334
Location:6 → 140

NDK; Nucleoside diphosphate kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

20788243..20796450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480031.1 → XP_021335706.1 nucleoside diphosphate kinase B isoform X1

UniProtKB/TrEMBL

A0A8M9PP44

Conserved Domains (1) summary

PTZ00093
Location:29 → 176

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional