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tim timeless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33571, updated on 29-Feb-2020

Summary

Official Symbol
timprovided by FlyBase
Official Full Name
timelessprovided by FlyBase
Primary source
FLYBASE:FBgn0014396
Locus tag
Dmel_CG3234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3234; Dmel\CG3234; dtim; dTim; dTIM; mel_tim; rit; Ritsu; s-tim; Tim; TIM; Tim-1; tim1

Genomic context

See tim in Genome Data Viewer
Location:
23F6-23F6; 2-10 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3493986..3508119, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3493986..3508119, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene thor Neighboring gene uncharacterized protein Neighboring gene snoRNA:Orphan CD box 16 Neighboring gene long non-coding RNA:CR45299 Neighboring gene antisense RNA:CR45300 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm NAS
Non-traceable Author Statement
more info
PubMed 
circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
circadian temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
copulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
eclosion rhythm NAS
Non-traceable Author Statement
more info
PubMed 
eclosion rhythm TAS
Traceable Author Statement
more info
PubMed 
entrainment of circadian clock IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
PubMed 
entrainment of circadian clock TAS
Traceable Author Statement
more info
PubMed 
locomotor rhythm IGI
Inferred from Genetic Interaction
more info
PubMed 
locomotor rhythm NAS
Non-traceable Author Statement
more info
PubMed 
mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative phototaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
photoperiodism IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus NAS
Non-traceable Author Statement
more info
PubMed 
regulation of circadian sleep/wake cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian sleep/wake cycle, sleep TAS
Traceable Author Statement
more info
PubMed 
regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein import into nucleus TAS
Traceable Author Statement
more info
PubMed 
replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork protection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rhythmic behavior TAS
Traceable Author Statement
more info
PubMed 
sleep NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
timeless
Names
CG3234-PB
CG3234-PL
CG3234-PM
CG3234-PN
CG3234-PO
CG3234-PP
CG3234-PR
CG3234-PS
CG3234-PT
TIMELESS
dtimeless
ritsu
tim-PB
tim-PL
tim-PM
tim-PN
tim-PO
tim-PP
tim-PR
tim-PS
tim-PT
timeless1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3493986..3508119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144308.3NP_001137780.2  timeless, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137780.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49021
    Related
    FBpp0305456, FBtr0333258
    Conserved Domains (1) summary
    pfam04821
    Location:25236
    TIMELESS; Timeless protein
  2. NM_164540.4NP_722912.3  timeless, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722912.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49021
    Related
    FBpp0305454, FBtr0333256
    Conserved Domains (1) summary
    pfam04821
    Location:25281
    TIMELESS; Timeless protein
  3. NM_001038783.3NP_001033872.2  timeless, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033872.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49021
    Related
    FBpp0305451, FBtr0333253
    Conserved Domains (1) summary
    pfam04821
    Location:25281
    TIMELESS; Timeless protein
  4. NM_001014463.4NP_001014463.2  timeless, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014463.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49021
    Related
    FBpp0305457, FBtr0333259
    Conserved Domains (1) summary
    pfam04821
    Location:25236
    TIMELESS; Timeless protein
  5. NM_001347756.1NP_001334730.1  timeless, isoform T [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1W5PW00
    Related
    FBpp0401565, FBtr0445397
  6. NM_164542.5NP_722914.3  timeless, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722914.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49021
    Related
    FBpp0077256, FBtr0077567
    Conserved Domains (1) summary
    pfam04821
    Location:25281
    TIMELESS; Timeless protein
  7. NM_164541.6NP_722913.3  timeless, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722913.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49021
    Related
    FBpp0305450, FBtr0333252
    Conserved Domains (1) summary
    pfam04821
    Location:25281
    TIMELESS; Timeless protein
  8. NM_001144309.4NP_001137781.2  timeless, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137781.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49021
    Related
    FBpp0305453, FBtr0333255
    Conserved Domains (1) summary
    pfam04821
    Location:25281
    TIMELESS; Timeless protein
  9. NM_001201757.2NP_001188686.2  timeless, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188686.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49021
    Related
    FBpp0305452, FBtr0333254
    Conserved Domains (1) summary
    pfam04821
    Location:25281
    TIMELESS; Timeless protein
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