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ptpn6 protein tyrosine phosphatase non-receptor type 6 [ Danio rerio (zebrafish) ]

Gene ID: 335573, updated on 16-Oct-2021

Summary

Official Symbol
ptpn6provided by ZNC
Official Full Name
protein tyrosine phosphatase non-receptor type 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7513
See related
Ensembl:ENSDARG00000089043
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Hcph; SHP1; fj22f05; zgc:55501; wu:fj22f05
Orthologs
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Genomic context

See ptpn6 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31720071..31757341, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (31765417..31801756, complement)
103 previous assembly Zv9 (GCF_000002035.4) 16 NC_007127.5 (34227447..34240643, complement) , (33958414..33978787, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily member 5-like Neighboring gene retinol binding protein 1a, cellular Neighboring gene chromodomain helicase DNA binding protein 4b Neighboring gene wingless-type MMTV integration site family, member 4b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 6
NP_956254.1
XP_009290703.1
XP_009290704.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199960.1NP_956254.1  tyrosine-protein phosphatase non-receptor type 6

    See identical proteins and their annotated locations for NP_956254.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044414
    UniProtKB/TrEMBL
    Q803M6
    Related
    ENSDARP00000105983.2, ENSDART00000126617.4
    Conserved Domains (4) summary
    cd09931
    Location:109212
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:3101
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:246517
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:276517
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    31720071..31757341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292429.3XP_009290704.1  tyrosine-protein phosphatase non-receptor type 6 isoform X2

    See identical proteins and their annotated locations for XP_009290704.1

    UniProtKB/TrEMBL
    E7F3D4
    Conserved Domains (4) summary
    cd09931
    Location:109212
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:3101
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:246517
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:276517
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_009292428.2XP_009290703.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

    Related
    ENSDARP00000148161.1, ENSDART00000185043.1
    Conserved Domains (4) summary
    cd09931
    Location:110213
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:4102
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:247518
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:277518
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394963.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1278..21739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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