Rab21 Rab21 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab21provided by FlyBase
Official Full Name: Rab21provided by FlyBase
Primary source: FLYBASE:FBgn0039966
Locus tag: Dmel_CG17515
See related: AllianceGenome:FB:FBgn0039966
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF45341; anon-EST:Posey237; CG17515; CG40304; Dmel\CG17515; DmRab21; Q7PLE8; Rab-21; rab21
Summary: Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in cortical actin cytoskeleton organization and positive regulation of autophagosome maturation. Located in early endosome. Is expressed in several structures, including Bolwig organ; adult ensheathing glial cell; brain; imaginal disc; and synaptic neuropil domain. Orthologous to human RAB21 (RAB21, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (23012140..23013409, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (22413976..22415245, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase catalytic subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	HDA more info	PubMed
located_in synapse	HDA more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info