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fbp1a fructose-1,6-bisphosphatase 1a [ Danio rerio (zebrafish) ]

Gene ID: 335231, updated on 9-Dec-2024

Summary

Official Symbol
fbp1aprovided by ZNC
Official Full Name
fructose-1,6-bisphosphatase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7171
See related
Ensembl:ENSDARG00000021366 AllianceGenome:ZFIN:ZDB-GENE-030131-7171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fbp1; fbp1l; fk92h02; zgc:64096; wu:fk92h02
Summary
Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and hexose metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; lens; liver; and solid lens vesicle. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See fbp1a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (44833313..44843738, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (44233160..44243585, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene cathepsin La Neighboring gene fructose-1,6-bisphosphatase 2 Neighboring gene KN motif and ankyrin repeat domains 1a Neighboring gene doublesex and mab-3 related transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
fructose-1,6-bisphosphatase 1a
Names
fructose-1,6-bisphosphatase 1, like
NP_956236.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199942.2NP_956236.1  fructose-1,6-bisphosphatase 1a

    See identical proteins and their annotated locations for NP_956236.1

    Status: VALIDATED

    Source sequence(s)
    CR388096, EH585004
    UniProtKB/TrEMBL
    A0A8N1TXV4, Q6PFT1
    Related
    ENSDARP00000004866.7, ENSDART00000003926.8
    Conserved Domains (1) summary
    cd00354
    Location:18332
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    44833313..44843738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)