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HTR1D 5-hydroxytryptamine receptor 1D [ Homo sapiens (human) ]

Gene ID: 3352, updated on 17-Jun-2024

Summary

Official Symbol
HTR1Dprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 1Dprovided by HGNC
Primary source
HGNC:HGNC:5289
See related
Ensembl:ENSG00000179546 MIM:182133; AllianceGenome:HGNC:5289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTRL; RDC4; HT1DA; 5-HT1D; HTR1DA
Summary
Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and intestine smooth muscle contraction. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See HTR1D in Genome Data Viewer
Location:
1p36.12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23191895..23217502, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23017572..23043163, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23518388..23543995, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine zipper protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23494055-23494586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23494587-23495118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 357 Neighboring gene RNA, U6 small nuclear 514, pseudogene Neighboring gene RNA, U6 small nuclear 135, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 407 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:23515051-23516250 Neighboring gene MPRA-validated peak115 silencer Neighboring gene MPRA-validated peak116 silencer Neighboring gene Sharpr-MPRA regulatory region 9970 Neighboring gene ribosomal protein L29 pseudogene 6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:23589770-23590604 Neighboring gene long intergenic non-protein coding RNA 1355

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 1D
Names
5-HT-1D
5-HT-1D-alpha
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
serotonin 1D alpha receptor
serotonin receptor 1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000864.5NP_000855.1  5-hydroxytryptamine receptor 1D

    See identical proteins and their annotated locations for NP_000855.1

    Status: VALIDATED

    Source sequence(s)
    AL049576, AL353585
    Consensus CDS
    CCDS231.1
    UniProtKB/Swiss-Prot
    P28221
    Related
    ENSP00000363748.1, ENST00000374619.2
    Conserved Domains (1) summary
    cd15333
    Location:35367
    7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    23191895..23217502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23017572..23043163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)