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capzb capping actin protein of muscle Z-line subunit beta [ Danio rerio (zebrafish) ]

Gene ID: 335083, updated on 9-Jun-2025
Official Symbol
capzbprovided by ZNC
Official Full Name
capping actin protein of muscle Z-line subunit betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7023
See related
Ensembl:ENSDARG00000100252 AllianceGenome:ZFIN:ZDB-GENE-030131-7023
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66149; wu:fk65f06
Summary
Predicted to enable actin filament binding activity. Acts upstream of or within muscle cell development and neural crest cell migration. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of F-actin capping protein complex. Is expressed in fin bud; head; pharyngeal arch; and somite. Used to study cleft palate. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
human mouse all
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See capzb in Genome Data Viewer
Location:
chromosome: 22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 22 NC_133197.1 (409373..424951)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 22 NC_007133.7 (396629..411299)

Chromosome 22 - NC_133197.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141380114 Neighboring gene transmembrane protein 88b-like Neighboring gene NBL1, DAN family BMP antagonist Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene dual serine/threonine and tyrosine protein kinase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Actin capping protein CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis†. Mukherjee K, et al. Hum Mol Genet, 2016 Apr 1. PMID 26758871, Free PMC Article
  2. Dietary lysine imbalance affects muscle proteome in zebrafish (Danio rerio): a comparative 2D-DIGE study. de Vareilles M, et al. Mar Biotechnol (NY), 2012 Oct. PMID 22580902
  3. Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos. Huang L, et al. Chemosphere, 2012 Apr. PMID 22209252
  4. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Hawkins TA, et al. Development, 2008 Mar. PMID 18256191, Free PMC Article
  5. Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Singh SK, et al. Zebrafish, 2010 Jun. PMID 20528263

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of F-actin capping protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of F-actin capping protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
F-actin-capping protein subunit beta
Names
capping protein (actin filament) muscle Z-line, beta

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199935.1 → NP_956229.1  F-actin-capping protein subunit beta

    See identical proteins and their annotated locations for NP_956229.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055514
    UniProtKB/TrEMBL
    A0A8M3ALX5, Q7SXP1
    Conserved Domains (1) summary
    pfam01115
    Location:11 → 239
    F_actin_cap_B; F-actin capping protein, beta subunit

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133197.1 Reference GRCz12tu Primary Assembly

    Range
    409373..424951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295745.4 → XP_009294020.1  F-actin-capping protein subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8M3AUB3
    Conserved Domains (1) summary
    pfam01115
    Location:11 → 239
    F_actin_cap_B; F-actin capping protein, beta subunit

  2. XM_009295746.5 → XP_009294021.1  F-actin-capping protein subunit beta isoform X2

    See identical proteins and their annotated locations for XP_009294021.1

    UniProtKB/TrEMBL
    A0A8M3ALX5, Q7SXP1
    Related
    ENSDARP00000140899.1
    Conserved Domains (1) summary
    pfam01115
    Location:11 → 239
    F_actin_cap_B; F-actin capping protein, beta subunit
Nucleotide Protein Strain
Heading Accession and Version

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