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gammaTub23C gamma-Tubulin at 23C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33501, updated on 6-Jul-2026
Official Symbol
gammaTub23Cprovided by FlyBase
Official Full Name
gamma-Tubulin at 23Cprovided by FlyBase
Primary source
FLYBASE:FBgn0260639
Locus tag
Dmel_CG3157
See related
AllianceGenome:FB:FBgn0260639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG 3157; CG3157; D.m.GAMMA-23C; Dmel\CG3157; g-Tubulin; gamma tubulin; gamma-tub; gamma-Tub; gamma-tub 23C; gamma-tub23; gamma-tub23C; gamma-Tub23C; gamma-tubulin; GAMMA23C; gammatub; gammaTub; gammaTUB; gammatub23C; gammaTub23c; gammaTUB23C; gammaTub23CD; gammatubulin; gamma[zy]; GTU88*; gTub; GTUB; gTub23C; l(2)23Ce; Tub23; Tub23C; Tub3A; tubulin
Summary
Enables GTP binding activity. Contributes to microtubule minus-end binding activity. Involved in microtubule cytoskeleton organization; mitotic sister chromatid separation; and regulation of cell cycle. Located in cytoplasm and microtubule cytoskeleton. Part of gamma-tubulin ring complex and gamma-tubulin small complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to human TUBG1 (tubulin gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See gammaTub23C in Genome Data Viewer
Location:
23C4-23C4; 2-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2972891..2974858)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2972891..2974858)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 9 Neighboring gene Thymidylate synthase Neighboring gene Recombination repair protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Drosophila centrosomes are unable to trigger parthenogenetic development of Xenopus eggs. Tournier F, et al. Biol Cell, 1999 Mar. PMID 10399825
  2. Mitotic phosphoepitopes are expressed in Kc cells, neuroblasts and isolated chromosomes of Drosophila melanogaster. Bousbaa H, et al. J Cell Sci, 1997 Sep. PMID 9378750
  3. Polar organization of gamma-tubulin in acentriolar mitotic spindles of Drosophila melanogaster cells. Debec A, et al. J Cell Sci, 1995 Jul. PMID 7593305
  4. Structure of the gamma-tubulin ring complex: a template for microtubule nucleation. Moritz M, et al. Nat Cell Biol, 2000 Jun. PMID 10854328
  5. Differential properties of the two Drosophila gamma-tubulin isotypes. Raynaud-Messina B, et al. Eur J Cell Biol, 2001 Oct. PMID 11713868

See all (306) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase, Pericentrin-like protein (Dplp), Asterless (Asl), Plk4 kinase, Centrosomin (Cnn) and gamma-tubulin.
    Title: Structured illumination of the interface between centriole and peri-centriolar material.
  2. The genetic interactions between gammaTub23C and chromatin-remodeling mutations suggest that gamma-tubulin might have a role in regulating gene expression.
    Title: gammaTub23C interacts genetically with brahma chromatin-remodeling complexes in Drosophila melanogaster.
  3. This indicates a role for Dgrip84 in regulating the activity and/or the location of the gamma-tubulin complexes formed with gammaTub37CD and gammaTub23C.
    Title: Distinct Dgrip84 isoforms correlate with distinct gamma-tubulins in Drosophila.
  4. findings showed that the molecular requirements for a functional spindle checkpoint included components of the large gamma-tubulin ring complex; however, their localization at the centrosome and centrosome integrity were not essential for this function
    Title: A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint.
  5. gamma-tubulin is required for female germ-cell proliferation and that the two gamma-tubulins present in Drosophila are functionally equivalent during female germ-cell development and oogenesis.
    Title: gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila.
  6. extensively recruited to the centrosome during mitosis and relocalizes in the mitotic spindle.
    Title: Differential properties of the two Drosophila gamma-tubulin isotypes.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl nucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microtubule minus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule nucleator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centriole-centriole cohesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule nucleation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle HMP PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid separation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin complex IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of gamma-tubulin ring complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin ring complex IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin ring complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of gamma-tubulin small complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of gamma-tubulin small complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
gamma-Tubulin at 23C
Names
23C gamma-tubulin
23C-gamma-tubulin
CG3157-PA
gama-tubulin
gamma tubulin
gamma tubulin 23C
gamma-Tubulin
gamma-tubulin (23C)
gamma-tubulin 23C
gamma-tubulin(23C)
gamma-tubulin-1
gamma-tubulin23C
gammaTub23C-PA
gammatubulin
lethal (2) 23Ce
tubulin

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2972891..2974858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057456.4 → NP_476804.1  gamma-Tubulin at 23C

    See identical proteins and their annotated locations for NP_476804.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P23257, Q9VQJ5
    Related
    FBpp0077326
    Conserved Domains (2) summary
    PLN00222
    Location:1 → 451
    PLN00222; tubulin gamma chain; Provisional
    cd02188
    Location:4 → 440
    gamma_tubulin; The gamma-tubulin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23257.2 P23257

Gene LinkOut

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