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Duox Dual oxidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33477, updated on 6-May-2021

Summary

Official Symbol
Duoxprovided by FlyBase
Official Full Name
Dual oxidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0283531
Locus tag
Dmel_CG3131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3131; Cy; dduox; dDuox; Dmel\CG3131; duox; duOx; DUOX; l(2)23Bb
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Genomic context

See Duox in Genome Data Viewer
Location:
23B2-23B3; 2-7 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2815970..2830248, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2815970..2830248, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene dawdle Neighboring gene uncharacterized protein Neighboring gene Glucose-6-Phosphatase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 23B

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD(P)H oxidase H2O2-forming activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables superoxide-generating NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adult chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult chitin-containing cuticle pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cuticle development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endomembrane system HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual oxidase
Names
CG3131-PB
CG3131-PC
Duox-PB
Duox-PC
NADPH dual oxidase
curly
NP_001259968.1
NP_608715.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2815970..2830248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273039.1NP_001259968.1  dual oxidase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259968.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQH2
    UniProtKB/TrEMBL
    M9PCF1
    Related
    FBpp0307132, FBtr0335133
    Conserved Domains (6) summary
    cd06186
    Location:12651536
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:72625
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:860921
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:10841217
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:70580
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:899965
    EF-hand_7; EF-hand domain pair
  2. NM_134871.3NP_608715.2  dual oxidase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608715.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQH2
    UniProtKB/TrEMBL
    M9PCF1
    Related
    FBpp0289611, FBtr0300382
    Conserved Domains (6) summary
    cd06186
    Location:12651536
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:72625
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:860921
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:10841217
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:70580
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:899965
    EF-hand_7; EF-hand domain pair
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