Format

Send to:

Choose Destination

HTN1 histatin 1 [ Homo sapiens (human) ]

Gene ID: 3346, updated on 23-Nov-2021

Summary

Official Symbol
HTN1provided by HGNC
Official Full Name
histatin 1provided by HGNC
Primary source
HGNC:HGNC:5283
See related
Ensembl:ENSG00000126550 MIM:142701
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIS1
Summary
This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]
Expression
Restricted expression toward salivary gland (RPKM 17545.5) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HTN1 in Genome Data Viewer
Location:
4q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (70050438..70058848)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70916155..70924565)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene statherin Neighboring gene histatin 3 Neighboring gene casein alpha s2 like A, pseudogene Neighboring gene casein alpha s2 like B, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to bacterium NAS
Non-traceable Author Statement
more info
PubMed 
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
involved_in killing of cells of other organism IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
histatin-1
Names
PPB
histidine-rich protein 1
post-PB protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368990.1NP_001355919.1  histatin-1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC063956
  2. NM_002159.4NP_002150.1  histatin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002150.1

    Status: REVIEWED

    Source sequence(s)
    AC063956
    Consensus CDS
    CCDS3534.1
    UniProtKB/Swiss-Prot
    P15515
    Related
    ENSP00000246896.3, ENST00000246896.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    70050438..70058848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171801.1 Reference GRCh38.p13 PATCHES

    Range
    90574..98984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center