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FOXN2 forkhead box N2 [ Homo sapiens (human) ]

Gene ID: 3344, updated on 23-Nov-2021

Summary

Official Symbol
FOXN2provided by HGNC
Official Full Name
forkhead box N2provided by HGNC
Primary source
HGNC:HGNC:5281
See related
Ensembl:ENSG00000170802 MIM:143089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTLF
Summary
This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 14.2), fat (RPKM 8.5) and 24 other tissues See more
Orthologs
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Genomic context

See FOXN2 in Genome Data Viewer
Location:
2p16.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (48314299..48379295)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (48541438..48606434)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 224 Neighboring gene uncharacterized LOC102724008 Neighboring gene RNA, U4 small nuclear 49, pseudogene Neighboring gene protein phosphatase 1 regulatory subunit 21 Neighboring gene STON1-GTF2A1L readthrough Neighboring gene RNA, U6 small nuclear 282, pseudogene Neighboring gene stonin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
forkhead box protein N2
Names
human T-cell leukemia virus enhancer factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375442.1NP_001362371.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-12 all encode the same isoform (a).
    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  2. NM_001375443.1NP_001362372.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  3. NM_001375444.1NP_001362373.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  4. NM_001375445.1NP_001362374.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  5. NM_001375446.1NP_001362375.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  6. NM_001375447.1NP_001362376.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  7. NM_001375448.1NP_001362377.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  8. NM_001375449.1NP_001362378.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  9. NM_001375450.1NP_001362379.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  10. NM_001375451.1NP_001362380.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  11. NM_001375452.1NP_001362381.1  forkhead box protein N2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
  12. NM_001375781.1NP_001362710.1  forkhead box protein N2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC091485
    Related
    ENSP00000388486.1, ENST00000413569.5
    Conserved Domains (1) summary
    pfam00250
    Location:111198
    Forkhead; Forkhead domain
  13. NM_002158.4NP_002149.2  forkhead box protein N2 isoform a

    See identical proteins and their annotated locations for NP_002149.2

    Status: REVIEWED

    Source sequence(s)
    AA827684, AC091485, BC063305
    Consensus CDS
    CCDS1838.1
    UniProtKB/Swiss-Prot
    P32314
    Related
    ENSP00000343633.3, ENST00000340553.8
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

RNA

  1. NR_164686.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC091485
  2. NR_164691.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC091485

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    48314299..48379295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264283.2XP_005264340.1  forkhead box protein N2 isoform X1

    See identical proteins and their annotated locations for XP_005264340.1

    UniProtKB/Swiss-Prot
    P32314
    Conserved Domains (1) summary
    cd20058
    Location:111192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)
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