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dpp decapentaplegic [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33432, updated on 12-Oct-2019

Summary

Official Symbol
dppprovided by FlyBase
Official Full Name
decapentaplegicprovided by FlyBase
Primary source
FLYBASE:FBgn0000490
Locus tag
Dmel_CG9885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
blk; BMP; CG9885; Dm-DPP; Dmel\CG9885; Dpp; DPP; DPP-C; Dpp/TGFbeta; Hin-d; ho; l(2)10638; l(2)22Fa; l(2)k17036; M(2)23AB; M(2)LS1; shv; Tg; TGF-b; TGF-beta; TGF-betagr;/SMAD; TGFbeta

Genomic context

See dpp in Genome Data Viewer
Location:
22F1-22F3; 2-6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2428372..2459823)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2428372..2459823)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44912 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tyrosine-GTA 1-2 Neighboring gene transfer RNA:Tyrosine-GTA 1-3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • BMP signaling, organism-specific biosystem (from KEGG)
    BMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • BMP signaling, conserved biosystem (from KEGG)
    BMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hedgehog signaling pathway - fly, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway - fly, organism-specific biosystemHedgehog (Hh) signaling plays essential roles in embryonic development and adult tissue homeostasis. It is first elucidated by genetic studies in Drosophila and the core of the Hh signaling pathway i...
  • MAPK signaling pathway - fly, organism-specific biosystem (from KEGG)
    MAPK signaling pathway - fly, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role i...
  • MAPK signaling pathway - fly, conserved biosystem (from KEGG)
    MAPK signaling pathway - fly, conserved biosystemThe mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role i...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by BMP, organism-specific biosystem (from REACTOME)
    Signaling by BMP, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
BMP receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
morphogen activity IGI
Inferred from Genetic Interaction
more info
PubMed 
morphogen activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogen activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
R8 cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amnioserosa formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
amnioserosa formation NAS
Non-traceable Author Statement
more info
PubMed 
amnioserosa formation TAS
Traceable Author Statement
more info
PubMed 
anterior Malpighian tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior axis specification TAS
Traceable Author Statement
more info
PubMed 
cardioblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell chemotaxis involved in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell fate specification TAS
Traceable Author Statement
more info
PubMed 
chorion-containing eggshell formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
compound eye morphogenesis TAS
Traceable Author Statement
more info
PubMed 
developmental pigmentation TAS
Traceable Author Statement
more info
PubMed 
dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal closure IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal closure TAS
Traceable Author Statement
more info
PubMed 
dorsal closure, leading edge cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ectoderm development TAS
Traceable Author Statement
more info
PubMed 
ectodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
ectodermal cell fate specification NAS
Non-traceable Author Statement
more info
PubMed 
embryonic hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell migration, open tracheal system TAS
Traceable Author Statement
more info
PubMed 
eye-antennal disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
eye-antennal disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
foregut morphogenesis TAS
Traceable Author Statement
more info
PubMed 
fusion cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
genital disc anterior/posterior pattern formation IEP
Inferred from Expression Pattern
more info
PubMed 
genital disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
genital disc development TAS
Traceable Author Statement
more info
PubMed 
genital disc sexually dimorphic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ-line stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
head morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development TAS
Traceable Author Statement
more info
PubMed 
hemocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindgut morphogenesis TAS
Traceable Author Statement
more info
PubMed 
imaginal disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc development TAS
Traceable Author Statement
more info
PubMed 
imaginal disc growth TAS
Traceable Author Statement
more info
PubMed 
imaginal disc pattern formation TAS
Traceable Author Statement
more info
PubMed 
imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc-derived wing morphogenesis TAS
Traceable Author Statement
more info
PubMed 
imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc-derived wing vein specification TAS
Traceable Author Statement
more info
PubMed 
labial disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
larval lymph gland hemocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
leg disc proximal/distal pattern formation NAS
Non-traceable Author Statement
more info
PubMed 
leg disc proximal/distal pattern formation TAS
Traceable Author Statement
more info
PubMed 
lymph gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal specification of dorsal/ventral axis, oocyte, soma encoded IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of gene expression IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of salivary gland boundary specification TAS
Traceable Author Statement
more info
PubMed 
nurse cell apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
open tracheal system development NAS
Non-traceable Author Statement
more info
PubMed 
open tracheal system development TAS
Traceable Author Statement
more info
PubMed 
ovarian follicle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle cell development TAS
Traceable Author Statement
more info
PubMed 
pericardial nephrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of muscle organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis TAS
Traceable Author Statement
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell shape TAS
Traceable Author Statement
more info
PubMed 
regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of tube diameter, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory organ development TAS
Traceable Author Statement
more info
PubMed 
spectrosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
wing and notum subfield formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
wing disc anterior/posterior pattern formation TAS
Traceable Author Statement
more info
PubMed 
wing disc pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
wing disc pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
wing disc proximal/distal pattern formation TAS
Traceable Author Statement
more info
PubMed 
zygotic specification of dorsal/ventral axis IMP
Inferred from Mutant Phenotype
more info
PubMed 
zygotic specification of dorsal/ventral axis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoneme IDA
Inferred from Direct Assay
more info
PubMed 
dense core granule lumen IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
decapentaplegic
Names
CG9885-PA
CG9885-PB
CG9885-PC
CG9885-PE
Decapentaplegic/Bone morphogenetic protein
Haplo-insufficient
blink
bone morphogenetic protein
bone morphogenic protein
dpp-PA
dpp-PB
dpp-PC
dpp-PE
heldout
shortvein
tegula

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2428372..2459823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057963.5NP_477311.1  decapentaplegic, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477311.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07713
    Related
    FBpp0077451, FBtr0077771
    Conserved Domains (2) summary
    smart00204
    Location:487588
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:225444
    TGFb_propeptide; TGF-beta propeptide
  2. NM_164485.2NP_722810.1  decapentaplegic, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722810.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07713
    Related
    FBpp0077452, FBtr0077772
    Conserved Domains (2) summary
    smart00204
    Location:487588
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:225444
    TGFb_propeptide; TGF-beta propeptide
  3. NM_164486.2NP_722811.1  decapentaplegic, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722811.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07713
    Related
    FBpp0077453, FBtr0077773
    Conserved Domains (2) summary
    smart00204
    Location:487588
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:225444
    TGFb_propeptide; TGF-beta propeptide
  4. NM_164488.2NP_722813.1  decapentaplegic, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722813.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07713
    Related
    FBpp0077455, FBtr0077775
    Conserved Domains (2) summary
    smart00204
    Location:487588
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:225444
    TGFb_propeptide; TGF-beta propeptide
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