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mat1a methionine adenosyltransferase 1A [ Danio rerio (zebrafish) ]

Gene ID: 334195, updated on 19-May-2025
Official Symbol
mat1aprovided by ZNC
Official Full Name
methionine adenosyltransferase 1Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6127
See related
Ensembl:ENSDARG00000039605 AllianceGenome:ZFIN:ZDB-GENE-030131-6127
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55442; wu:fi35e01
Summary
Predicted to enable methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including anterior neural tube; lens; liver; optic cup; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A). [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See mat1a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 13 NC_133188.1 (20589606..20597830, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 13 NC_007124.7 (18628907..18637151, complement)

Chromosome 13 - NC_133188.1Genomic Context describing neighboring genes Neighboring gene finTRIM family, member 14-like Neighboring gene zgc:154058 Neighboring gene uncharacterized LOC141377003 Neighboring gene U2 spliceosomal RNA Neighboring gene U2 spliceosomal RNA

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny. Adam AC, et al. PLoS One, 2018. PMID 30070994, Free PMC Article
  2. Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid. Adam AC, et al. PLoS One, 2019. PMID 31398226, Free PMC Article
  3. The gene history of zebrafish tlr4a and tlr4b is predictive of their divergent functions. Sullivan C, et al. J Immunol, 2009 Nov 1. PMID 19812203, Free PMC Article
  4. Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Thomas JK, et al. Aquat Toxicol, 2013 Apr 15. PMID 23399444
  5. Cardiac and Metabolic Effects of Dietary Selenomethionine Exposure in Adult Zebrafish. Pettem CM, et al. Toxicol Sci, 2017 Oct 1. PMID 28962524

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine adenosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
S-adenosylmethionine synthase isoform type-1
Names
methionine adenosyltransferase I, alpha
NP_956165.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199871.1 → NP_956165.1  S-adenosylmethionine synthase isoform type-1

    See identical proteins and their annotated locations for NP_956165.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045343
    UniProtKB/TrEMBL
    A0A0R4IXB6, A0A8N7XJ85, B2GPU4, Q7ZW04
    Related
    ENSDARP00000057868.3, ENSDART00000057869.4
    Conserved Domains (4) summary
    PTZ00104
    Location:11 → 389
    PTZ00104; S-adenosylmethionine synthase; Provisional
    pfam00438
    Location:12 → 109
    S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
    pfam02772
    Location:124 → 245
    S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
    pfam02773
    Location:247 → 383
    S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133188.1 Reference GRCz12tu Primary Assembly

    Range
    20589606..20597830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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