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bcan brevican [ Danio rerio (zebrafish) ]

Gene ID: 334113, updated on 9-Sep-2025
Official Symbol
bcanprovided by ZNC
Official Full Name
brevicanprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6045
See related
Ensembl:ENSDARG00000099412 AllianceGenome:ZFIN:ZDB-GENE-030131-6045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi32a12; wu:fi32a12
Summary
Predicted to enable carbohydrate binding activity and hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region. Predicted to be active in extracellular space; perineuronal net; and synapse. Is expressed in VeLD and forebrain. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human BCAN (brevican). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See bcan in Genome Data Viewer
Location:
chromosome: 16
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 16 NC_133191.1 (32441492..32500962, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29309885..29361436, complement)

Chromosome 16 - NC_133191.1Genomic Context describing neighboring genes Neighboring gene Rh family B glycoprotein Neighboring gene uncharacterized LOC141378214 Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene methyltransferase like 25B

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. Kang JS, et al. Mech Dev, 2004 Mar. PMID 15003632
  2. A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Staudt N, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25490391, Free PMC Article
  3. A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Gao X, et al. Cell Rep, 2015 Jul 28. PMID 26190107
  4. Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Martin S, et al. Mol Cell Proteomics, 2010 Dec. PMID 20802085, Free PMC Article
  5. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in perineuronal net IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
brevican core protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083813.3 → NP_001077282.3  brevican core protein precursor

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000016
    Related
    ENSDARP00000140252.1, ENSDART00000162835.2

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133191.1 Reference GRCz12tu Primary Assembly

    Range
    32441492..32500962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073924638.1 → XP_073780739.1  brevican core protein isoform X2

    UniProtKB/TrEMBL
    A0AB32T475, A0AB32T608

  2. XM_073924637.1 → XP_073780738.1  brevican core protein isoform X1

    UniProtKB/TrEMBL
    A0AB32T475

  3. XM_073924640.1 → XP_073780741.1  brevican core protein isoform X4

    UniProtKB/TrEMBL
    A4JYN2

  4. XM_073924639.1 → XP_073780740.1  brevican core protein isoform X3

    UniProtKB/TrEMBL
    A4JYN2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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